Mycobacterium avium and mycobacterium intracellulare infections in patients with and without aids

Linda S. Guthertz, Beca Damsker, Edward J. Bottone, Eleanor G. Ford, Thaddeus E. Midura, J. Michael Janda

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104 Scopus citations

Abstract

A genetic probe (Gen-Probe) was used to evaluate potential epidemiologic and susceptibility differences of Mycobacterium avium complex (MAC) strains isolated from 154 patients with and without the acquired immunodeficiency syndrome (AIDS). Genetic analysis revealed that 98% of the 45 patients with AIDS harbored only M. avium regardless of the anatomic or geographic source of the isolate; in contrast, -40% of MAC isolates recovered from 109 patients without AIDS were M. intracellulare. Most M. intracellulare of respiratory origin recovered from patients without AIDS were involved in infectious processes. When 95 MAC isolates (M avium, n = 53; M. intracellulare, n = 42) were evaluated for in vitro susceptibility to primary or secondary antimycobacterial drugs, significant differences were noted. M. intracellulare was more susceptible to streptomycin, rifampin, and ethambutol than M. avium\ the converse was true for ethionamide. The results of this study suggest potentially important differences in disease spectrum and in vitro susceptibility profile for M. avium and M. intracellulare.

Original languageEnglish
Pages (from-to)1037-1041
Number of pages5
JournalJournal of Infectious Diseases
Volume160
Issue number6
DOIs
StatePublished - Dec 1989

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