TY - JOUR
T1 - MYC and the control of DNA replication
AU - Dominguez-Sola, David
AU - Gautier, Jean
N1 - Publisher Copyright:
© 2014 Cold Spring Harbor Laboratory Press; all rights reserved.
PY - 2014
Y1 - 2014
N2 - The MYC oncogene is a multifunctional protein that is aberrantly expressed in a significant fraction of tumors from diverse tissue origins. Because of its multifunctional nature, it has been difficult to delineate the exact contributions of MYC’s diverse roles to tumorigenesis. Here, we review the normal role of MYC in regulating DNA replication as well as its ability to generate DNA replication stress when overexpressed. Finally, we discuss the possible mech- anisms by which replication stress induced by aberrant MYC expression could contribute to genomic instability and cancer.
AB - The MYC oncogene is a multifunctional protein that is aberrantly expressed in a significant fraction of tumors from diverse tissue origins. Because of its multifunctional nature, it has been difficult to delineate the exact contributions of MYC’s diverse roles to tumorigenesis. Here, we review the normal role of MYC in regulating DNA replication as well as its ability to generate DNA replication stress when overexpressed. Finally, we discuss the possible mech- anisms by which replication stress induced by aberrant MYC expression could contribute to genomic instability and cancer.
UR - http://www.scopus.com/inward/record.url?scp=84891752437&partnerID=8YFLogxK
U2 - 10.1101/cshperspect.a014423
DO - 10.1101/cshperspect.a014423
M3 - Article
C2 - 24890833
AN - SCOPUS:84891752437
SN - 2157-1422
VL - 4
JO - Cold Spring Harbor Perspectives in Medicine
JF - Cold Spring Harbor Perspectives in Medicine
IS - 6
ER -