Mutations in DNA repair genes are associated with increased neoantigen burden and a distinct immunophenotype in lung squamous cell carcinoma

Keyphrases

• Immunophenotyping 100%
• Lung Squamous Cell Carcinoma 100%
• DNA Repair Genes 100%
• Neoantigen 100%
• DNA Repair Pathways 66%
• Mismatch Repair 66%
• Lung Cancer 33%
• Tumor 33%
• DNA Repair 33%
• Cancer Genome Atlas 33%
• Immune Checkpoint 33%
• Homologous Recombination 33%
• Wnt Signaling Pathway 33%
• T Cell Infiltration 33%
• Pathway Genes 33%
• Activated T Cells 33%
• Gene Variants 33%
• Cytolytic Activity 33%
• Tumor Infiltration 33%
• Tumor mutation Burden 33%
• Biomarkers for Immunotherapy 33%
• Gene Repair 33%
• Tumor Neoantigen Burden 33%
• Immunomodulatory Genes 33%
• Polymerase epsilon 33%
• Immune Cell Infiltration 33%
• Immune Checkpoint Inhibitors 33%
• High Tumor mutation Burden 33%
• Repair Status 33%

Immunology and Microbiology

• Neoantigen 100%
• Squamous Cell 100%
• DNA Repair 100%
• Lung 100%
• Repair Gene 100%
• T Cell 33%
• Mismatch Repair 33%
• Immunotherapy 16%
• Upregulation 16%
• Immune Cell Infiltration 16%
• Cell Infiltration 16%
• Homologous Recombination 16%
• Wnt Signaling 16%
• Immune Checkpoint Inhibitor 16%

Biochemistry, Genetics and Molecular Biology

• DNA Repair 100%
• Immunophenotyping 100%
• Repair Gene 100%
• T Cell 33%
• Cell Infiltration 33%
• DNA Mismatch Repair 33%
• Upregulation 16%
• Immunocompetent Cell 16%
• Wnt Signaling Pathway 16%
• Polymerase 16%
• Immune Checkpoints 16%
• Homologous Recombination 16%
• Gene Repair 16%
• Deficiency 16%
• Immune Checkpoint Inhibitor 16%