TY - JOUR
T1 - Mutational landscape of gastric adenocarcinoma in Latin America
T2 - A genetic approach for precision medicine
AU - Cerrato-Izaguirre, Dennis
AU - Chirino, Yolanda I.
AU - García-Cuellar, Claudia M.
AU - Santibáñez-Andrade, Miguel
AU - Prada, Diddier
AU - Hernández-Guerrero, Angélica
AU - Larraga, Octavio Alonso
AU - Camacho, Javier
AU - Sánchez-Pérez, Yesennia
N1 - Publisher Copyright:
© 2021 Chongqing Medical University
PY - 2022/7
Y1 - 2022/7
N2 - Latin-America (LATAM) is the second region in gastric cancer incidence; gastric adenocarcinoma (GA) represents 95% of all cases. We provide a mutational landscape of GA highlighting a) germline pathogenic variants associated with hereditary GA, b) germline risk variants associated with sporadic GA, and c) somatic variants present in sporadic GA in LATAM, and analyze how this landscape can be applied for precision medicine. We found that Brazil, Chile, Colombia, Mexico, Peru, and Venezuela are the countries with more published studies from LATAM explicitly related to GA. Our analysis displayed that different germline pathogenic variants for the CDH1 gene have been identified for hereditary GA in Brazilian, Chilean, Colombian, and Mexican populations. An increased risk of developing somatic GA is associated with the following germline risk variants: IL-4, IL-8, TNF-α, PTGS2, NFKB1, RAF1, KRAS and MAPK1 in Brazilian; IL-10 in Chilean; IL-10 in Colombian; EGFR and ERRB2 in Mexican, TCF7L2 and Chr8q24 in Venezuelan population. The path from mutational landscape to precision medicine requires four development levels: 1) Data compilation, 2) Data analysis and integration, 3) Development and approval of clinical approaches, and 4) Population benefits. Generating local genomic information is the initial padlock to overcome to generate and apply precision medicine.
AB - Latin-America (LATAM) is the second region in gastric cancer incidence; gastric adenocarcinoma (GA) represents 95% of all cases. We provide a mutational landscape of GA highlighting a) germline pathogenic variants associated with hereditary GA, b) germline risk variants associated with sporadic GA, and c) somatic variants present in sporadic GA in LATAM, and analyze how this landscape can be applied for precision medicine. We found that Brazil, Chile, Colombia, Mexico, Peru, and Venezuela are the countries with more published studies from LATAM explicitly related to GA. Our analysis displayed that different germline pathogenic variants for the CDH1 gene have been identified for hereditary GA in Brazilian, Chilean, Colombian, and Mexican populations. An increased risk of developing somatic GA is associated with the following germline risk variants: IL-4, IL-8, TNF-α, PTGS2, NFKB1, RAF1, KRAS and MAPK1 in Brazilian; IL-10 in Chilean; IL-10 in Colombian; EGFR and ERRB2 in Mexican, TCF7L2 and Chr8q24 in Venezuelan population. The path from mutational landscape to precision medicine requires four development levels: 1) Data compilation, 2) Data analysis and integration, 3) Development and approval of clinical approaches, and 4) Population benefits. Generating local genomic information is the initial padlock to overcome to generate and apply precision medicine.
KW - Ethnicities
KW - Genome
KW - Latin America
KW - Mutation
KW - Precision medicine
KW - Stomach neoplasms
UR - https://www.scopus.com/pages/publications/85107885342
U2 - 10.1016/j.gendis.2021.04.002
DO - 10.1016/j.gendis.2021.04.002
M3 - Review article
AN - SCOPUS:85107885342
SN - 2352-4820
VL - 9
SP - 928
EP - 940
JO - Genes and Diseases
JF - Genes and Diseases
IS - 4
ER -