TY - JOUR
T1 - Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
AU - Podsypanina, Katrina
AU - Ellenson, Lora Hedrick
AU - Nemes, Adriana
AU - Gu, Jianguo
AU - Tamura, Masahito
AU - Yamada, Kenneth M.
AU - Cordon-Cardo, Carlos
AU - Catoretti, Giorgio
AU - Fisher, Peter E.
AU - Parsons, Ramon
PY - 1999/2/16
Y1 - 1999/2/16
N2 - Pten/Mmac1+/- heterozygous mice exhibited neoplasms in multiple organs including the endometrium, liver, prostate, gastrointestinal tract, thyroid, and thymus. Loss of the wild-type allele was detected in neoplasms of the thymus and liver. Surprisingly, tumors of the gastrointestinal epithelium developed in association with gut lymphoid tissue. Tumors of the endometrium, thyroid, prostate, and liver were not associated with lymphoid tissue and appeared to be highly mitotic. In addition, these mice have nonneoplastic hyperplasia of lymph nodes that was caused by an inherited defect in apoptosis detected in B cells and macrophages. Examination of peripheral lymphoid tissue including lymphoid aggregates associated with polyps revealed that the normal organization of B and T cells was disrupted in heterozygous animals. Taken together, these data suggest that PTEN is a regulator of apoptosis and proliferation that behaves as a 'landscaper' tumor suppressor in the gut and a 'gatekeeper' tumor suppressor in other organs.
AB - Pten/Mmac1+/- heterozygous mice exhibited neoplasms in multiple organs including the endometrium, liver, prostate, gastrointestinal tract, thyroid, and thymus. Loss of the wild-type allele was detected in neoplasms of the thymus and liver. Surprisingly, tumors of the gastrointestinal epithelium developed in association with gut lymphoid tissue. Tumors of the endometrium, thyroid, prostate, and liver were not associated with lymphoid tissue and appeared to be highly mitotic. In addition, these mice have nonneoplastic hyperplasia of lymph nodes that was caused by an inherited defect in apoptosis detected in B cells and macrophages. Examination of peripheral lymphoid tissue including lymphoid aggregates associated with polyps revealed that the normal organization of B and T cells was disrupted in heterozygous animals. Taken together, these data suggest that PTEN is a regulator of apoptosis and proliferation that behaves as a 'landscaper' tumor suppressor in the gut and a 'gatekeeper' tumor suppressor in other organs.
UR - http://www.scopus.com/inward/record.url?scp=13044250465&partnerID=8YFLogxK
U2 - 10.1073/pnas.96.4.1563
DO - 10.1073/pnas.96.4.1563
M3 - Article
C2 - 9990064
AN - SCOPUS:13044250465
SN - 0027-8424
VL - 96
SP - 1563
EP - 1568
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 4
ER -