Mutants of purine metabolism in cultured mouse and hamster cells

Kenneth H. Astrin, C. Thomas Caskey

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The regulation of purine metabolism in mammalian cells is poorly understood presently. A variety of mutants in hamster and mouse is now available for these studies. It is clear that selective methods provide the potential for isolation of a greater variety and number of such mutants. It is predicted that the methods are now available for extensive study of the purine biosynthetic pathway with respect to both its genetic organization and cellular regulation. These mouse and hamster mutants will undoubtedly facilitate our understanding of this multistep pathway which until recently has been limited to the study of rare human mutants.

Original languageEnglish
Pages (from-to)397-410
Number of pages14
JournalArchives of Biochemistry and Biophysics
Issue number2
StatePublished - Oct 1976
Externally publishedYes


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