Musculoskeletal regeneration research network: A global initiative

Kai Ming Chan; Christer G. Rolf; Ling Qin; Li Felländer-Tsai; Rene M. Castelein; Daniël B.F. Saris; Jos Malda; Geoff Richards; Stuart B. Goodman; Rocky S. Tuan; William Maloney; Lars Lidgren; Chelsea Hopkins; Sai Chuen Fu; Gang Li; Ming Ding; Ting Ting Tang; Xiao Ling Zhang; Lei Wei; Herb B. Sun; Hong Wei Ouyang

doi:10.1016/j.jot.2015.08.007

Musculoskeletal regeneration research network: A global initiative

Kai Ming Chan
, Christer G. Rolf
, Ling Qin
, Li Felländer-Tsai
, Rene M. Castelein
, Daniël B.F. Saris
, Jos Malda
, Geoff Richards
, Stuart B. Goodman
, Rocky S. Tuan
, William Maloney
, Lars Lidgren
, Chelsea Hopkins
, Sai Chuen Fu
, Gang Li
, Ming Ding
, Ting Ting Tang
, Xiao Ling Zhang
, Lei Wei
, Herb B. Sun

Hong Wei Ouyang

Research output: Contribution to journal › Editorial

1 Scopus citations

Original language	English
Pages (from-to)	160-165
Number of pages	6
Journal	Journal of Orthopaedic Translation
Volume	3
Issue number	4
DOIs	https://doi.org/10.1016/j.jot.2015.08.007
State	Published - 1 Oct 2015
Externally published	Yes

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10.1016/j.jot.2015.08.007

Cite this

Chan, K. M., Rolf, C. G., Qin, L., Felländer-Tsai, L., Castelein, R. M., Saris, D. B. F., Malda, J., Richards, G., Goodman, S. B., Tuan, R. S., Maloney, W., Lidgren, L., Hopkins, C., Fu, S. C., Li, G., Ding, M., Tang, T. T., Zhang, X. L., Wei, L., ... Ouyang, H. W. (2015). Musculoskeletal regeneration research network: A global initiative. Journal of Orthopaedic Translation, 3(4), 160-165. https://doi.org/10.1016/j.jot.2015.08.007

@article{24b80bfcb9cf497ead87ca94ea0e3218,

title = "Musculoskeletal regeneration research network: A global initiative",

author = "Chan, \{Kai Ming\} and Rolf, \{Christer G.\} and Ling Qin and Li Fell{\"a}nder-Tsai and Castelein, \{Rene M.\} and Saris, \{Dani{\"e}l B.F.\} and Jos Malda and Geoff Richards and Goodman, \{Stuart B.\} and Tuan, \{Rocky S.\} and William Maloney and Lars Lidgren and Chelsea Hopkins and Fu, \{Sai Chuen\} and Gang Li and Ming Ding and Tang, \{Ting Ting\} and Zhang, \{Xiao Ling\} and Lei Wei and Sun, \{Herb B.\} and Ouyang, \{Hong Wei\}",

note = "Funding Information: Based on the Fragility Fracture Network model [6] , the MRN aims at bringing together like-minded researchers from global institutions, focusing on MSK regeneration and turning basic science into translatable results. In the past 5 years, the MRN has taken the necessary steps to build a firm foundation and expand to include illustrious institutions, allowing access to new grants, publication of more research, and providing staff and students the opportunity to learn and share expertise and knowledge beneficial to both the host and home institutions [7] . For example, the collaboration between The Chinese University of Hong Kong (CUHK) and Karolinska Institute (KI) has already achieved numerous benefits. KI has access to a large number of human tendinopathy samples for the analysis of microbial presence, while CUHK has cell-culture facilities to study the pathogenesis of microbes on the development of tendinopathy. The project has expanded its collaborative efforts to Uppsala University, by virtue of its bioinformatics facilities. Furthermore, the collaborating institutions were approached by the University Hospital of Trondheim, Norway, supplying additional tendinopathy samples to increase sample and demographic size in the study. A similar collaborative platform has been established between CUHK and University Medical Centre Utrecht. University Medical Centre Utrecht has developed hydrogel three-dimensional printing technology for regeneration of focal chondral defects, while CUHK is working on injectable products to treat degenerative osteoarthritis, with a shared interest in developing value-added biomaterials for these applications. Recently, CUHK researchers visited the University of Southern Denmark, and held a joint symposium on MSK regeneration. A formal Memorandum of Understanding (MOU) has been signed and a project is being planned for the development of bioactive constructs, wherein both institutions will apply for research grants, establish a joint PhD programme, and share resources and facilities. Delegates from CUHK recently visited Stanford University, CA, USA (Stanford delegates have previously visited CUHK), under the auspices of a signed MOU between the two institutions, to initiate lectures and formulate new research bonds in various MSK fields. A similar, research-focused MOU is also in place between the University of Pittsburgh, PA, USA and CUHK. In addition, opportunities for collaboration in research, education, grants, and publication in both academia and industry are also being developed. Researchers from the AO Foundation, Shanghai Jiao Tong University, and CUHK have formed the European and Chinese RAPIDOS consortium, to collaborate on the project titled “rapid prototyping of custom-made bone-forming tissue engineering constructs,” which received funding from the European Commission and the National Natural Science Foundation of China in 2013 [8] . Furthermore, the collaboration between Shanghai Jiao Tong University and CUHK has produced another study on tendinopathy and tendon regeneration, which has resulted in the sharing of resources and facilities, education opportunities, and a number of publications [9–11] . Further collaboration is also under development with Brown University and CUHK, in which a publication studying stromal-cell-derived factor-1 and osteoarthritis has been published [12] , as well as facilitating scholars and students from CUHK to visit Brown University. ",

year = "2015",

month = oct,

day = "1",

doi = "10.1016/j.jot.2015.08.007",

language = "English",

volume = "3",

pages = "160--165",

journal = "Journal of Orthopaedic Translation",

issn = "2214-031X",

publisher = "Elsevier (Singapore) Pte Ltd",

number = "4",

}

Chan, KM, Rolf, CG, Qin, L, Felländer-Tsai, L, Castelein, RM, Saris, DBF, Malda, J, Richards, G, Goodman, SB, Tuan, RS, Maloney, W, Lidgren, L, Hopkins, C, Fu, SC, Li, G, Ding, M, Tang, TT, Zhang, XL, Wei, L, Sun, HB & Ouyang, HW 2015, 'Musculoskeletal regeneration research network: A global initiative', Journal of Orthopaedic Translation, vol. 3, no. 4, pp. 160-165. https://doi.org/10.1016/j.jot.2015.08.007

TY - JOUR

T1 - Musculoskeletal regeneration research network

T2 - A global initiative

AU - Chan, Kai Ming

AU - Rolf, Christer G.

AU - Qin, Ling

AU - Felländer-Tsai, Li

AU - Castelein, Rene M.

AU - Saris, Daniël B.F.

AU - Malda, Jos

AU - Richards, Geoff

AU - Goodman, Stuart B.

AU - Tuan, Rocky S.

AU - Maloney, William

AU - Lidgren, Lars

AU - Hopkins, Chelsea

AU - Fu, Sai Chuen

AU - Li, Gang

AU - Ding, Ming

AU - Tang, Ting Ting

AU - Zhang, Xiao Ling

AU - Wei, Lei

AU - Sun, Herb B.

AU - Ouyang, Hong Wei

N1 - Funding Information: Based on the Fragility Fracture Network model [6] , the MRN aims at bringing together like-minded researchers from global institutions, focusing on MSK regeneration and turning basic science into translatable results. In the past 5 years, the MRN has taken the necessary steps to build a firm foundation and expand to include illustrious institutions, allowing access to new grants, publication of more research, and providing staff and students the opportunity to learn and share expertise and knowledge beneficial to both the host and home institutions [7] . For example, the collaboration between The Chinese University of Hong Kong (CUHK) and Karolinska Institute (KI) has already achieved numerous benefits. KI has access to a large number of human tendinopathy samples for the analysis of microbial presence, while CUHK has cell-culture facilities to study the pathogenesis of microbes on the development of tendinopathy. The project has expanded its collaborative efforts to Uppsala University, by virtue of its bioinformatics facilities. Furthermore, the collaborating institutions were approached by the University Hospital of Trondheim, Norway, supplying additional tendinopathy samples to increase sample and demographic size in the study. A similar collaborative platform has been established between CUHK and University Medical Centre Utrecht. University Medical Centre Utrecht has developed hydrogel three-dimensional printing technology for regeneration of focal chondral defects, while CUHK is working on injectable products to treat degenerative osteoarthritis, with a shared interest in developing value-added biomaterials for these applications. Recently, CUHK researchers visited the University of Southern Denmark, and held a joint symposium on MSK regeneration. A formal Memorandum of Understanding (MOU) has been signed and a project is being planned for the development of bioactive constructs, wherein both institutions will apply for research grants, establish a joint PhD programme, and share resources and facilities. Delegates from CUHK recently visited Stanford University, CA, USA (Stanford delegates have previously visited CUHK), under the auspices of a signed MOU between the two institutions, to initiate lectures and formulate new research bonds in various MSK fields. A similar, research-focused MOU is also in place between the University of Pittsburgh, PA, USA and CUHK. In addition, opportunities for collaboration in research, education, grants, and publication in both academia and industry are also being developed. Researchers from the AO Foundation, Shanghai Jiao Tong University, and CUHK have formed the European and Chinese RAPIDOS consortium, to collaborate on the project titled “rapid prototyping of custom-made bone-forming tissue engineering constructs,” which received funding from the European Commission and the National Natural Science Foundation of China in 2013 [8] . Furthermore, the collaboration between Shanghai Jiao Tong University and CUHK has produced another study on tendinopathy and tendon regeneration, which has resulted in the sharing of resources and facilities, education opportunities, and a number of publications [9–11] . Further collaboration is also under development with Brown University and CUHK, in which a publication studying stromal-cell-derived factor-1 and osteoarthritis has been published [12] , as well as facilitating scholars and students from CUHK to visit Brown University.

PY - 2015/10/1

Y1 - 2015/10/1

UR - https://www.scopus.com/pages/publications/85028952644

U2 - 10.1016/j.jot.2015.08.007

DO - 10.1016/j.jot.2015.08.007

M3 - Editorial

AN - SCOPUS:85028952644

SN - 2214-031X

VL - 3

SP - 160

EP - 165

JO - Journal of Orthopaedic Translation

JF - Journal of Orthopaedic Translation

IS - 4

ER -