Murine Modeling of Myeloproliferative Neoplasms

Karie Chen, Alan H. Shih

Research output: Contribution to journalReview articlepeer-review


Myeloproliferative neoplasms, such as polycythemia vera, essential thrombocythemia, and primary myelofibrosis, are bone marrow disorders that result in the overproduction of mature clonal myeloid elements. Identification of recurrent genetic mutations has been described and aid in diagnosis and prognostic determination. Mouse models of these mutations have confirmed the biologic significance of these mutations in myeloproliferative neoplasm disease biology and provided greater insights on the pathways that are dysregulated with each mutation. The models are useful tools that have led to preclinical testing and provided data as validation for future myeloproliferative neoplasm clinical trials.

Original languageEnglish
Pages (from-to)253-265
Number of pages13
JournalHematology/Oncology Clinics of North America
Issue number2
StatePublished - Apr 2021


  • CALR
  • Epigenetics
  • JAK2
  • MPL
  • Mouse model
  • Myeloproliferative neoplasm
  • Preclinical trial


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