TY - JOUR
T1 - Multisystem inflammatory syndrome in children related to COVID-19
T2 - A New York City experience
AU - Riollano-Cruz, Mariawy
AU - Akkoyun, Esra
AU - Briceno-Brito, Eudys
AU - Kowalsky, Shanna
AU - Reed, James
AU - Posada, Roberto
AU - Sordillo, Emilia Mia
AU - Tosi, Michael
AU - Trachtman, Rebecca
AU - Paniz-Mondolfi, Alberto
N1 - Publisher Copyright:
© 2020 Wiley Periodicals LLC
PY - 2021/1
Y1 - 2021/1
N2 - In December 2019, the 2019, a novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) first emerged in Wuhan, China. This has now spread worldwide and was declared a pandemic by March 2020. Initially, the pediatric population was described as a low risk for severe COVID-19. However, reports have emerged recently of cases of COVID-19 in children with a systemic inflammatory disease, with features that overlap with Kawasaki disease (KD). We describe the first 15 cases with the multi-systeminflammatory syndrome in children (MIS-C), temporally related to COVID-19, who presented for care to a tertiary pediatric referral center in New York City. We discuss the disproportionate burden of disease among Hispanic/Latino and Black/African American ancestry, the distinct cytokine signature across the disease spectrum (IL-1/IL-6), and the potential role and pathogenesis of SARS-CoV-2 in this new clinical entity.
AB - In December 2019, the 2019, a novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) first emerged in Wuhan, China. This has now spread worldwide and was declared a pandemic by March 2020. Initially, the pediatric population was described as a low risk for severe COVID-19. However, reports have emerged recently of cases of COVID-19 in children with a systemic inflammatory disease, with features that overlap with Kawasaki disease (KD). We describe the first 15 cases with the multi-systeminflammatory syndrome in children (MIS-C), temporally related to COVID-19, who presented for care to a tertiary pediatric referral center in New York City. We discuss the disproportionate burden of disease among Hispanic/Latino and Black/African American ancestry, the distinct cytokine signature across the disease spectrum (IL-1/IL-6), and the potential role and pathogenesis of SARS-CoV-2 in this new clinical entity.
KW - COVID-19
KW - Kawasaki disease
KW - SARS-CoV-2
KW - hyperinflammatory syndrome
UR - http://www.scopus.com/inward/record.url?scp=85090144326&partnerID=8YFLogxK
U2 - 10.1002/jmv.26224
DO - 10.1002/jmv.26224
M3 - Article
C2 - 32584487
AN - SCOPUS:85090144326
VL - 93
SP - 424
EP - 433
JO - Journal of Medical Virology
JF - Journal of Medical Virology
SN - 0146-6615
IS - 1
ER -