Multisystem inflammatory syndrome in children related to COVID-19: A New York City experience

Mariawy Riollano-Cruz, Esra Akkoyun, Eudys Briceno-Brito, Shanna Kowalsky, James Reed, Roberto Posada, Emilia Mia Sordillo, Michael Tosi, Rebecca Trachtman, Alberto Paniz-Mondolfi

Research output: Contribution to journalArticlepeer-review

103 Scopus citations


In December 2019, the 2019, a novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) first emerged in Wuhan, China. This has now spread worldwide and was declared a pandemic by March 2020. Initially, the pediatric population was described as a low risk for severe COVID-19. However, reports have emerged recently of cases of COVID-19 in children with a systemic inflammatory disease, with features that overlap with Kawasaki disease (KD). We describe the first 15 cases with the multi-systeminflammatory syndrome in children (MIS-C), temporally related to COVID-19, who presented for care to a tertiary pediatric referral center in New York City. We discuss the disproportionate burden of disease among Hispanic/Latino and Black/African American ancestry, the distinct cytokine signature across the disease spectrum (IL-1/IL-6), and the potential role and pathogenesis of SARS-CoV-2 in this new clinical entity.

Original languageEnglish
Pages (from-to)424-433
Number of pages10
JournalJournal of Medical Virology
Issue number1
StatePublished - Jan 2021


  • COVID-19
  • Kawasaki disease
  • SARS-CoV-2
  • hyperinflammatory syndrome


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