Novel multistranded, alternative, and helical transitional nucleic acid microarrays allow the anchoring of nondenatured, intact, conventional DNAs and RNAs; alternative nucleic acids (e.g., Z-DNA); and multistranded nucleic acid (e.g., triplex DNA) molecules. They also permit the study of transitional changes that occur in the structure of DNA and RNA (e.g., B-DNA to Z-DNA: transcription studies). All of these conventional and nonconventional nucleic acids are anchored by a variety of different surface chemistries onto a novel solid support surface. This methodology represents the next generation of nucleic acid microarrays, and will hasten the discovery of new medicines that bind to nonconventional nucleic acids (i.e., turn off gene expression).
|Number of pages||6|
|Specialist publication||American Laboratory|
|State||Published - Mar 2011|