Multiscale network analysis identifies potential receptors for SARS-CoV-2 and reveals their tissue-specific and age-dependent expression

Christian V. Forst, Lu Zeng, Qian Wang, Xianxiao Zhou, Sezen Vatansever, Peng Xu, Won Min Song, Zhidong Tu, Bin Zhang

Research output: Contribution to journalArticlepeer-review

Abstract

The coronavirus disease 2019 (COVID-19) pandemic has affected tens of millions of individuals and caused hundreds of thousands of deaths worldwide. Here, we present a comprehensive, multiscale network analysis of the transcriptional response to the virus. In particular, we focused on key regulators, cell receptors, and host processes that were hijacked by the virus for its advantage. ACE2-controlled processes involved CD300e (a TYROBP receptor) as a key regulator and the activation of IL-2 pro-inflammatory cytokine signaling. We further investigated the age dependency of such receptors in different tissues. In summary, this study provides novel insights into the gene regulatory organization during the SARS-CoV-2 infection and the tissue-specific, age-dependent expression of the cell receptors involved in COVID-19.

Original languageEnglish
Pages (from-to)1384-1402
Number of pages19
JournalFEBS Letters
Volume597
Issue number10
DOIs
StatePublished - May 2023

Keywords

  • CD300e
  • COVID-19
  • age dependency
  • in silico validation
  • multiscale modeling

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