Multiscale modeling of cell shape from the actin cytoskeleton

Padmini Rangamani, Granville Yuguang Xiong, Ravi Iyengar

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

8 Scopus citations

Abstract

The actin cytoskeleton is a dynamic structure that constantly undergoes complex reorganization events during many cellular processes. Mathematical models and simulations are powerful tools that can provide insight into the physical mechanisms underlying these processes and make predictions that can be experimentally tested. Representation of the interactions of the actin filaments with the plasma membrane and the movement of the plasma membrane for computation remains a challenge. Here, we provide an overview of the different modeling approaches used to study cytoskeletal dynamics and highlight the differential geometry approach that we have used to implement the interactions between the plasma membrane and the cytoskeleton. Using cell spreading as an example, we demonstrate how this approach is able to successfully capture in simulations, experimentally observed behavior. We provide a perspective on how the differential geometry approach can be used for other biological processes.

Original languageEnglish
Title of host publicationComputational Neuroscience
PublisherElsevier
Pages143-167
Number of pages25
ISBN (Print)9780123978974
DOIs
StatePublished - 2014

Publication series

NameProgress in Molecular Biology and Translational Science
Volume123
ISSN (Print)1877-1173

Keywords

  • Actin cytoskeleton
  • Brownian ratchet
  • Cell spreading
  • Modeling
  • Motility

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