Multiple subpial transections in the language cortex

Orrin Devinsky, Kenneth Perrine, Blanca Vazquez, Daniel J. Luciano, Michael Dogali

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


Summary: Multiple subpial transections (MST) were made in language cortex in three patients with medically refractory partial epilepsy. All patients were mapped with extra-operative stimulation using subdural grids over the dominant temporal, frontal and parietal convexity. Two patients had anterior temporal lobectomy and MST in posterior language cortex. One patient who had undergone a previous frontal tumour resection had only MST over the frontoparietal convexity, including frontal and parietal language areas. Both patients with MST in the posterior language cortex had postoperative language dysfunction, which had improved significantly by 9 months after surgery. The patient with MST in frontoparietal language areas had improved language functions immediately postoperatively. The two men with anterior temporal lobectomies and MST are seizure-free at 1 year follow-up and the woman with fronto-parietal MST has had a >70% reduction in seizure frequency at 1 year follow-up.

Original languageEnglish
Pages (from-to)255-265
Number of pages11
Issue number2
StatePublished - Apr 1994
Externally publishedYes


  • Aphasia
  • Electrical stimulation
  • Epilepsy
  • Language
  • Surgery


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