Multiple pregnancies: Risk factors and prognostic variables during induction of ovulation with human menopausal gonadotrophins

Daniel Navot, Nurith Goldstein, Shlomo Mor-josef, Alex Simon, Abraham Relou, Arie Birkenfeld

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Multiple pregnancies still constitute a major and relatively frequent complication of induction of ovulation by human menopausal gonadotrophins (HMG) despite the increasing sophistication of monitoring techniques. In order to define specific variables which may be associated with multiple pregnancies, we have compared 51 multiple pregnancy cycles to 51 consecutive control singleton pregnancy cycles, following HMG induction of ovulation. The aetiology and classification of anovulation, duration of infertility, total amount of HMG utilized per cycle and the duration of stimulation were not associated with an increase in the rate of multiple pregnancy. Basal serum oestradiol levels and its periovulatory pattern were remarkably similar in the singleton and multiple pregnancy groups. The mean age of the multiple pregnancy group (29.4±4.4 years) was significantly lower than the mean age of the singleton pregnancy group (31.6±5.3 years) (P <0.05). In the multiple pregnancy group, there were significantly more cycles with intermediate sized (15-17 mm). (P <0.002), small sized (12-14 mm). (P <0.02) and Immature follicles (<12 mm) (P <0.03), at the time of human chorionic gonadotrophin (HCG) administration, as compared with the singleton pregnancy group. Furthermore, a direct linear correlation was observed between the number of intermediate sized follicles and number of implanted embryos. The presence of intermediate sized follicles at the time of HCG administration after HMG induction of follicular maturation is predictive of, and independently associated with, a higher incidence of multiple pregnancy.

Original languageEnglish
Pages (from-to)1152-1155
Number of pages4
JournalHuman Reproduction
Volume6
Issue number8
DOIs
StatePublished - Sep 1991

Keywords

  • Multiple pregnancy
  • Ovulation induction

Fingerprint

Dive into the research topics of 'Multiple pregnancies: Risk factors and prognostic variables during induction of ovulation with human menopausal gonadotrophins'. Together they form a unique fingerprint.

Cite this