Multiple Myeloma Risk and Outcomes Are Associated with Pathogenic Germline Variants in DNA Repair Genes

Keyphrases

• BRCA2 100%
• Multiple Myeloma 100%
• DNA Repair Genes 100%
• High-risk Myeloma 100%
• Pathogenic Germline Variant 100%
• Autosomal Dominant 66%
• Cancer Predisposition 66%
• Breast Cancer Susceptibility Gene 1 (BRCA1) 33%
• Young Age 33%
• Exome 33%
• Healthy Controls 33%
• Germ Cells 33%
• Patient Relatives 33%
• Age at Diagnosis 33%
• First-degree Relatives 33%
• Moderate Penetrance 33%
• Copy number Variation 33%
• Tumor-specific 33%
• Loss of Heterozygosity 33%
• Allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT) 33%
• Cancer History 33%
• High Penetrance 33%
• Familial Cancer 33%
• High-dose Melphalan 33%
• Long Progression-free Survival 33%
• Hereditary Cancer Genes 33%

Biochemistry, Genetics and Molecular Biology

• DNA Repair 100%
• Germline 100%
• Germ Cell 100%
• BRCA2 75%
• Autosomal Dominant Inheritance 50%
• BRCA1 25%
• Drug Megadose 25%
• Oncogene 25%
• Penetrance 25%
• Exome 25%
• Loss of Heterozygosity 25%
• Melphalan 25%
• Progression Free Survival 25%
• Autologous Stem Cell Transplantation 25%