Multiple lymphomatous polyposis of the gastrointestinal tract: Prospective clinicopathologic study of 31 cases

A. Ruskone-Fourmestraux; A. Delmer; A. Lavergne; T. Molina; N. Brousse; J. Audouin; J. C. Rambaud; C. Matuchansky; B. Messing; Y. Bouhnik; A. Bitoun; J. Cosnes; F. Carbonnel; J. P. Gendre; R. Jian; M. Lemann; R. Modigliani; P. Pescatore; B. Rio; R. Zittoun; J. D. Grange; P. Opolon; C. Buffet; F. Prat; G. Pelletier; C. Eugene; A. Boruchowichz; J. F. Colombel; H. Louvet; L. Legoux; L. Le Bodic; J. P. Galmiche; R. Lemaire

doi:10.1016/S0016-5085(97)70212-9

Multiple lymphomatous polyposis of the gastrointestinal tract: Prospective clinicopathologic study of 31 cases

A. Ruskone-Fourmestraux, A. Delmer, A. Lavergne, T. Molina, N. Brousse, J. Audouin, J. C. Rambaud, C. Matuchansky, B. Messing, Y. Bouhnik, A. Bitoun, J. Cosnes, F. Carbonnel, J. P. Gendre, R. Jian, M. Lemann, R. Modigliani, P. Pescatore, B. Rio, R. ZittounJ. D. Grange, P. Opolon, C. Buffet, F. Prat, G. Pelletier, C. Eugene, A. Boruchowichz, J. F. Colombel, H. Louvet, L. Legoux, L. Le Bodic, J. P. Galmiche, R. Lemaire

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Abstract

Background and Aims: Multiple lymphomatous polyposis (MLP) is an uncommon type of gastrointestinal lymphoma. The aim of this study was to analyze the clinicopathologic features and outcome of a large series of patients. Methods: From 1984 to 1995, 31 patients were enrolled prospectively. Exhaustive staging and immunohistochemical analysis were performed. The first 10 patients were treated with cyclophosphamide- vincristine-prednisolone (COP) and the subsequent 21 with doxorubicin- teniposide-cyclophosphamide-prednisolone (AVmCP). Eleven patients were treated with high-dose radiochemotherapy and stem cell autotransplantation because of partial response or relapse. Results: Advanced age and multiple polyps involving several gastrointestinal segments characterized initial clinical presentation. The typical tumor cell phenotype (pan-B⁺, CD5⁺, and CD10^-) along with Bcl-1 rearrangement indicated that MLP is the gastrointestinal counterpart of mantle cell lymphoma. After COP treatment, only 3 patients achieved partial remissions, whereas 80% of patients after AVmCP treatment achieved complete or good partial remission. High-dose radiochemotherapy changed partial into complete remission in 80% of cases. None of the initial 10 patients survived for 3 years, but the expected 5- year survival rate was 59% in patients receiving the anthracycline-containing regimen (P < 0.0001). Conclusions: MLP is a distinct entity among gastrointestinal lymphomas. An anthracycline-containing multidrug regimen and high-dose radiochemotherapy supported by autotransplantation seem to improve its poor prognosis.

Original language	English
Pages (from-to)	7-16
Number of pages	10
Journal	Gastroenterology
Volume	112
Issue number	1
DOIs	https://doi.org/10.1016/S0016-5085(97)70212-9
State	Published - 1997
Externally published	Yes

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Ruskone-Fourmestraux, A., Delmer, A., Lavergne, A., Molina, T., Brousse, N., Audouin, J., Rambaud, J. C., Matuchansky, C., Messing, B., Bouhnik, Y., Bitoun, A., Cosnes, J., Carbonnel, F., Gendre, J. P., Jian, R., Lemann, M., Modigliani, R., Pescatore, P., Rio, B., ... Lemaire, R. (1997). Multiple lymphomatous polyposis of the gastrointestinal tract: Prospective clinicopathologic study of 31 cases. Gastroenterology, 112(1), 7-16. https://doi.org/10.1016/S0016-5085(97)70212-9

@article{9cf017891bfb49d39340e201e73d2b9d,

title = "Multiple lymphomatous polyposis of the gastrointestinal tract: Prospective clinicopathologic study of 31 cases",

abstract = "Background and Aims: Multiple lymphomatous polyposis (MLP) is an uncommon type of gastrointestinal lymphoma. The aim of this study was to analyze the clinicopathologic features and outcome of a large series of patients. Methods: From 1984 to 1995, 31 patients were enrolled prospectively. Exhaustive staging and immunohistochemical analysis were performed. The first 10 patients were treated with cyclophosphamide- vincristine-prednisolone (COP) and the subsequent 21 with doxorubicin- teniposide-cyclophosphamide-prednisolone (AVmCP). Eleven patients were treated with high-dose radiochemotherapy and stem cell autotransplantation because of partial response or relapse. Results: Advanced age and multiple polyps involving several gastrointestinal segments characterized initial clinical presentation. The typical tumor cell phenotype (pan-B+, CD5+, and CD10-) along with Bcl-1 rearrangement indicated that MLP is the gastrointestinal counterpart of mantle cell lymphoma. After COP treatment, only 3 patients achieved partial remissions, whereas 80% of patients after AVmCP treatment achieved complete or good partial remission. High-dose radiochemotherapy changed partial into complete remission in 80% of cases. None of the initial 10 patients survived for 3 years, but the expected 5- year survival rate was 59% in patients receiving the anthracycline-containing regimen (P < 0.0001). Conclusions: MLP is a distinct entity among gastrointestinal lymphomas. An anthracycline-containing multidrug regimen and high-dose radiochemotherapy supported by autotransplantation seem to improve its poor prognosis.",

author = "A. Ruskone-Fourmestraux and A. Delmer and A. Lavergne and T. Molina and N. Brousse and J. Audouin and Rambaud, {J. C.} and C. Matuchansky and B. Messing and Y. Bouhnik and A. Bitoun and J. Cosnes and F. Carbonnel and Gendre, {J. P.} and R. Jian and M. Lemann and R. Modigliani and P. Pescatore and B. Rio and R. Zittoun and Grange, {J. D.} and P. Opolon and C. Buffet and F. Prat and G. Pelletier and C. Eugene and A. Boruchowichz and Colombel, {J. F.} and H. Louvet and L. Legoux and {Le Bodic}, L. and Galmiche, {J. P.} and R. Lemaire",

year = "1997",

doi = "10.1016/S0016-5085(97)70212-9",

language = "English",

volume = "112",

pages = "7--16",

journal = "Gastroenterology",

issn = "0016-5085",

publisher = "W.B. Saunders",

number = "1",

}

Ruskone-Fourmestraux, A, Delmer, A, Lavergne, A, Molina, T, Brousse, N, Audouin, J, Rambaud, JC, Matuchansky, C, Messing, B, Bouhnik, Y, Bitoun, A, Cosnes, J, Carbonnel, F, Gendre, JP, Jian, R, Lemann, M, Modigliani, R, Pescatore, P, Rio, B, Zittoun, R, Grange, JD, Opolon, P, Buffet, C, Prat, F, Pelletier, G, Eugene, C, Boruchowichz, A, Colombel, JF, Louvet, H, Legoux, L, Le Bodic, L, Galmiche, JP & Lemaire, R 1997, 'Multiple lymphomatous polyposis of the gastrointestinal tract: Prospective clinicopathologic study of 31 cases', Gastroenterology, vol. 112, no. 1, pp. 7-16. https://doi.org/10.1016/S0016-5085(97)70212-9

TY - JOUR

T1 - Multiple lymphomatous polyposis of the gastrointestinal tract

T2 - Prospective clinicopathologic study of 31 cases

AU - Ruskone-Fourmestraux, A.

AU - Delmer, A.

AU - Lavergne, A.

AU - Molina, T.

AU - Brousse, N.

AU - Audouin, J.

AU - Rambaud, J. C.

AU - Matuchansky, C.

AU - Messing, B.

AU - Bouhnik, Y.

AU - Bitoun, A.

AU - Cosnes, J.

AU - Carbonnel, F.

AU - Gendre, J. P.

AU - Jian, R.

AU - Lemann, M.

AU - Modigliani, R.

AU - Pescatore, P.

AU - Rio, B.

AU - Zittoun, R.

AU - Grange, J. D.

AU - Opolon, P.

AU - Buffet, C.

AU - Prat, F.

AU - Pelletier, G.

AU - Eugene, C.

AU - Boruchowichz, A.

AU - Colombel, J. F.

AU - Louvet, H.

AU - Legoux, L.

AU - Le Bodic, L.

AU - Galmiche, J. P.

AU - Lemaire, R.

PY - 1997

Y1 - 1997

N2 - Background and Aims: Multiple lymphomatous polyposis (MLP) is an uncommon type of gastrointestinal lymphoma. The aim of this study was to analyze the clinicopathologic features and outcome of a large series of patients. Methods: From 1984 to 1995, 31 patients were enrolled prospectively. Exhaustive staging and immunohistochemical analysis were performed. The first 10 patients were treated with cyclophosphamide- vincristine-prednisolone (COP) and the subsequent 21 with doxorubicin- teniposide-cyclophosphamide-prednisolone (AVmCP). Eleven patients were treated with high-dose radiochemotherapy and stem cell autotransplantation because of partial response or relapse. Results: Advanced age and multiple polyps involving several gastrointestinal segments characterized initial clinical presentation. The typical tumor cell phenotype (pan-B+, CD5+, and CD10-) along with Bcl-1 rearrangement indicated that MLP is the gastrointestinal counterpart of mantle cell lymphoma. After COP treatment, only 3 patients achieved partial remissions, whereas 80% of patients after AVmCP treatment achieved complete or good partial remission. High-dose radiochemotherapy changed partial into complete remission in 80% of cases. None of the initial 10 patients survived for 3 years, but the expected 5- year survival rate was 59% in patients receiving the anthracycline-containing regimen (P < 0.0001). Conclusions: MLP is a distinct entity among gastrointestinal lymphomas. An anthracycline-containing multidrug regimen and high-dose radiochemotherapy supported by autotransplantation seem to improve its poor prognosis.

AB - Background and Aims: Multiple lymphomatous polyposis (MLP) is an uncommon type of gastrointestinal lymphoma. The aim of this study was to analyze the clinicopathologic features and outcome of a large series of patients. Methods: From 1984 to 1995, 31 patients were enrolled prospectively. Exhaustive staging and immunohistochemical analysis were performed. The first 10 patients were treated with cyclophosphamide- vincristine-prednisolone (COP) and the subsequent 21 with doxorubicin- teniposide-cyclophosphamide-prednisolone (AVmCP). Eleven patients were treated with high-dose radiochemotherapy and stem cell autotransplantation because of partial response or relapse. Results: Advanced age and multiple polyps involving several gastrointestinal segments characterized initial clinical presentation. The typical tumor cell phenotype (pan-B+, CD5+, and CD10-) along with Bcl-1 rearrangement indicated that MLP is the gastrointestinal counterpart of mantle cell lymphoma. After COP treatment, only 3 patients achieved partial remissions, whereas 80% of patients after AVmCP treatment achieved complete or good partial remission. High-dose radiochemotherapy changed partial into complete remission in 80% of cases. None of the initial 10 patients survived for 3 years, but the expected 5- year survival rate was 59% in patients receiving the anthracycline-containing regimen (P < 0.0001). Conclusions: MLP is a distinct entity among gastrointestinal lymphomas. An anthracycline-containing multidrug regimen and high-dose radiochemotherapy supported by autotransplantation seem to improve its poor prognosis.

UR - http://www.scopus.com/inward/record.url?scp=0031022235&partnerID=8YFLogxK

U2 - 10.1016/S0016-5085(97)70212-9

DO - 10.1016/S0016-5085(97)70212-9

M3 - Article

C2 - 8978336

AN - SCOPUS:0031022235

SN - 0016-5085

VL - 112

SP - 7

EP - 16

JO - Gastroenterology

JF - Gastroenterology

IS - 1

ER -

Multiple lymphomatous polyposis of the gastrointestinal tract: Prospective clinicopathologic study of 31 cases

Abstract

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