Multiple functions of the IKK-related kinase IKKε in interferon-mediated antiviral immunity

Benjamin R. TenOever, Sze Ling Ng, Mark A. Chua, Sarah M. McWhirter, Adolfo García-Sastre, Tom Maniatis

Research output: Contribution to journalArticlepeer-review

278 Scopus citations

Abstract

IKKε is an IKK (inhibitor of nuclear factor κB kinase)-related kinase implicated in virus induction of interferon-β (IFNβ). We report that, although mice lacking IKKε produce normal amounts of IFNβ, they are hypersusceptible to viral infection because of a defect in the IFN signaling pathway. Specifically, a subset of type I IFN-stimulated genes are not activated in the absence of IKKε because the interferon-stimulated gene factor 3 complex (ISGF3) does not bind to promoter elements of the affected genes. We demonstrate that IKKε is activated by IFNβ and that IKKε directly phosphorylates signal transducer and activator of transcription 1 (STAT1), a component of ISGF3. We conclude that IKKε plays a critical role in the IFN-inducible antiviral transcriptional response.

Original languageEnglish
Pages (from-to)1274-1278
Number of pages5
JournalScience
Volume315
Issue number5816
DOIs
StatePublished - 2 Mar 2007

Fingerprint

Dive into the research topics of 'Multiple functions of the IKK-related kinase IKKε in interferon-mediated antiviral immunity'. Together they form a unique fingerprint.

Cite this