Multiple and multifocal carcinomas in female genital organs and breast

Liane Deligdisch, A. E. Szulman

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Sixty-seven cases of multiple primary malignant tumors of the genital organs and breast were analyzed in their different combinations. A percentage of 5.4% of multiple primary tumors was found in a cancer population of 1235. In addition, cases of multifocal primary carcinoma in symmetrical organs (breasts and ovaries) were discussed. A higher incidence of multiple primary cancers was found in embryologically related organs, such as vulva, vagina and uterine exocervix, or endometrium and ovary. Endometriosis with malignant foci was frequently found associated with the multiple primary tumors of the mullerian derived organs. Carcinoma in situ was found synchronously with overt multiple and multifocal carcinoma of the female genital organs and breasts and therefore considered as a previous stage of the carcinomatous progression. The area response of the embryologically related organs was discussed as a factor in the genesis of the multiple and multifocal multiple primary tumors of the female genital organs and breast.

Original languageEnglish
Pages (from-to)181-190
Number of pages10
JournalGynecologic Oncology
Issue number3
StatePublished - Sep 1975
Externally publishedYes


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