Multiple adipose depots increase cardiovascular risk via local and systemic effects topical collection on clinical trials and their interpretations

Kalypso Karastergiou, Susan K. Fried

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Adipose tissue modifies the development of cardiovascular disease in a complex manner: obesity is a major risk factor, especially when accompanied by a central fat distribution. For that reason the characteristics of visceral adipose tissue have attracted most of the research interest thus far, and measurement of waist circumference is now recommended for everyday clinical practice. However, the direct, causative role of visceral fat in cardiometabolic disease remains to be established. Epidemiological and clinical studies show that accumulation of fat subcutaneously, in the gluteofemoral area, is protective against cardiovascular disease, but the exact molecular mechanisms remain unclear. In the last few years, imaging has allowed the study of smaller fat depots that may interact locally with important tissues: epicardial fat with the myocardium, perivascular fat with the vessel wall and the developing atherosclerotic plaque, and renal sinus fat with the renal artery. Unraveling the heterogeneous fat distribution and metabolic phenotypes in human obesity will facilitate optimal assessment of cardiovascular risk in overweight and obese individuals.

Original languageEnglish
Article number361
JournalCurrent Atherosclerosis Reports
Volume15
Issue number10
DOIs
StatePublished - Oct 2013
Externally publishedYes

Keywords

  • Epicardial adipose tissue
  • Gluteofemoral adipose tissue
  • Renal sinus adipose tissue
  • Subcutaneous adipose tissue
  • Visceral adipose tissue

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