TY - JOUR
T1 - Multimodal voxel-based meta-analysis of white matter abnormalities in obsessive-compulsive disorder
AU - Radua, Joaquim
AU - Grau, Mar
AU - Van Den Heuvel, Odile A.
AU - Thiebaut De Schotten, Michel
AU - Stein, Dan J.
AU - Canales-Rodríguez, Erick J.
AU - Catani, Marco
AU - Mataix-Cols, David
N1 - Funding Information:
We thank all the authors of the included studies and very specially Drs Gong, Kwon, Lazaro, Murat, Nakao, Nakamae, Perani, Pujol, Rauch, Szeszko and colleagues for kindly sharing unpublished peak data and SPMs for inclusion in this meta-analysis. We also thank Dr Nemat Jaafari who helped retrieving papers in the early phases of this study. This work was supported by Instituto de Salud Carlos III (Río Hortega research contract to Dr Radua, CM11/00024). The funding organization had no role in the study design, data collection and analysis, or manuscript approval.
Funding Information:
Dr Canales-Rodríguez, Dr Catani and Dr Mataix-Cols declare that, except for income received from their primary employers, no financial support or compensation has been received from any individual or corporate entity over the past 3 years for research or professional service and there are no personal financial holdings that could be perceived as constituting a potential conflict of interest. Dr Radua has been a clinical rater in Roche clinical trials. Dr Grau has received funds from Alicia Koplowitz Foundation. Dr van den Heuvel has received a speaker honorarium from Eli Lilly. Dr Thiebaut de Schotten has received a research grant from Shire. Dr Stein has received research grants and/or consultancy honoraria from Biocodex, Eli-Lilly, GlaxoS-mithKline, Lundbeck, and Servier.
PY - 2014/6
Y1 - 2014/6
N2 - White matter (WM) abnormalities have long been suspected in obsessive-compulsive disorder (OCD) but the available evidence has been inconsistent. We conducted the first multimodal meta-analysis of WM volume (WMV) and fractional anisotropy (FA) studies in OCD. All voxel-wise studies comparing WMV or FA between patients with OCD and healthy controls in the PubMed, ScienceDirect, Google Scholar, Web of Knowledge and Scopus databases were retrieved. Manual searches were also conducted and authors were contacted soliciting additional data. Thirty-four data sets were identified, of which 22 met inclusion criteria (five of them unpublished; comprising 537 adult and pediatric patients with OCD and 575 matched healthy controls). Whenever possible, raw statistical parametric maps were also obtained from the authors. Peak and raw WMV and FA data were combined using novel multimodal meta-analytic methods implemented in effect-size signed differential mapping. Patients with OCD showed widespread WM abnormalities, but findings were particularly robust in the anterior midline tracts (crossing between anterior parts of cingulum bundle and body of corpus callosum), which showed both increased WMV and decreased FA, possibly suggesting an increase of fiber crossing in these regions. This finding was also observed when the analysis was limited to adult participants, and especially pronounced in samples with a higher proportion of medicated patients. Therefore, patients with OCD may have widespread WM abnormalities, particularly evident in anterior midline tracts, although these changes might be, at least in part, attributable to the effects of therapeutic drugs.
AB - White matter (WM) abnormalities have long been suspected in obsessive-compulsive disorder (OCD) but the available evidence has been inconsistent. We conducted the first multimodal meta-analysis of WM volume (WMV) and fractional anisotropy (FA) studies in OCD. All voxel-wise studies comparing WMV or FA between patients with OCD and healthy controls in the PubMed, ScienceDirect, Google Scholar, Web of Knowledge and Scopus databases were retrieved. Manual searches were also conducted and authors were contacted soliciting additional data. Thirty-four data sets were identified, of which 22 met inclusion criteria (five of them unpublished; comprising 537 adult and pediatric patients with OCD and 575 matched healthy controls). Whenever possible, raw statistical parametric maps were also obtained from the authors. Peak and raw WMV and FA data were combined using novel multimodal meta-analytic methods implemented in effect-size signed differential mapping. Patients with OCD showed widespread WM abnormalities, but findings were particularly robust in the anterior midline tracts (crossing between anterior parts of cingulum bundle and body of corpus callosum), which showed both increased WMV and decreased FA, possibly suggesting an increase of fiber crossing in these regions. This finding was also observed when the analysis was limited to adult participants, and especially pronounced in samples with a higher proportion of medicated patients. Therefore, patients with OCD may have widespread WM abnormalities, particularly evident in anterior midline tracts, although these changes might be, at least in part, attributable to the effects of therapeutic drugs.
KW - Cingulum bundle
KW - diffusion tensor imaging
KW - multimodal meta-analysis
KW - obsessive-compulsive disorder
KW - superior longitudinal fasciculus
KW - voxel-based morphometry
UR - http://www.scopus.com/inward/record.url?scp=84900565202&partnerID=8YFLogxK
U2 - 10.1038/npp.2014.5
DO - 10.1038/npp.2014.5
M3 - Article
C2 - 24407265
AN - SCOPUS:84900565202
SN - 0893-133X
VL - 39
SP - 1547
EP - 1557
JO - Neuropsychopharmacology
JF - Neuropsychopharmacology
IS - 7
ER -