TY - JOUR
T1 - Multimodal and simultaneous assessments of brain and spinal fluid abnormalities in chronic fatigue syndrome and the effects of psychiatric comorbidity
AU - Natelson, Benjamin H.
AU - Mao, Xiangling
AU - Stegner, Aaron J.
AU - Lange, Gudrun
AU - Vu, Diana
AU - Blate, Michelle
AU - Kang, Guoxin
AU - Soto, Eli
AU - Kapusuz, Tolga
AU - Shungu, Dikoma C.
N1 - Publisher Copyright:
© 2017
PY - 2017/4/15
Y1 - 2017/4/15
N2 - The purpose of this study was to investigate whether CFS patients without comorbid psychiatric diagnoses differ from CFS patients with comorbid psychiatric diagnoses and healthy control subjects in neuropsychological performance, the proportion with elevated spinal fluid protein or white cell counts, cerebral blood flow (CBF), brain ventricular lactate and cortical glutathione (GSH). The results of the study did not show any differences in any of the outcome measures between CFS patients with and without psychiatric comorbidity, thus indicating that psychiatric status may not be an exacerbating factor in CFS. Importantly, significant differences were found between the pooled samples of CFS compared to controls. These included lower GSH and CBF and higher ventricular lactate and rates of spinal fluid abnormalities in CFS patients compared to healthy controls. Thirteen of 26 patients had abnormal values on two or more of these 4 brain-related variables. These findings, which replicate the results of several of our prior studies, support the presence of a number of neurobiological and spinal fluid abnormalities in CFS. These results will lead to further investigation into objective biomarkers of the disorder to advance the understanding of CFS.
AB - The purpose of this study was to investigate whether CFS patients without comorbid psychiatric diagnoses differ from CFS patients with comorbid psychiatric diagnoses and healthy control subjects in neuropsychological performance, the proportion with elevated spinal fluid protein or white cell counts, cerebral blood flow (CBF), brain ventricular lactate and cortical glutathione (GSH). The results of the study did not show any differences in any of the outcome measures between CFS patients with and without psychiatric comorbidity, thus indicating that psychiatric status may not be an exacerbating factor in CFS. Importantly, significant differences were found between the pooled samples of CFS compared to controls. These included lower GSH and CBF and higher ventricular lactate and rates of spinal fluid abnormalities in CFS patients compared to healthy controls. Thirteen of 26 patients had abnormal values on two or more of these 4 brain-related variables. These findings, which replicate the results of several of our prior studies, support the presence of a number of neurobiological and spinal fluid abnormalities in CFS. These results will lead to further investigation into objective biomarkers of the disorder to advance the understanding of CFS.
UR - http://www.scopus.com/inward/record.url?scp=85014087738&partnerID=8YFLogxK
U2 - 10.1016/j.jns.2017.02.046
DO - 10.1016/j.jns.2017.02.046
M3 - Article
C2 - 28320179
AN - SCOPUS:85014087738
SN - 0022-510X
VL - 375
SP - 411
EP - 416
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
ER -