@article{d1c7d3d7770c4e1f85302a49c5081735,
title = "Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma",
abstract = "Integration of high-dimensional multi-omics approaches to characterize human cutaneous squamous cell carcinoma identifies a tumor-specific keratinocyte population as well as the immune infiltrates and heterogeneity at tumor leading edges.",
keywords = "CRISPR screen, MIBI, intra-tumoral heterogeneity, multi-omics, scRNA-seq, skin cancer, spatial transcriptomics, squamous cell carcinoma, tumor immunology, tumor microenvironment",
author = "Ji, {Andrew L.} and Rubin, {Adam J.} and Kim Thrane and Sizun Jiang and Reynolds, {David L.} and Meyers, {Robin M.} and Guo, {Margaret G.} and George, {Benson M.} and Annelie Mollbrink and Joseph Bergenstr{\aa}hle and Ludvig Larsson and Yunhao Bai and Bokai Zhu and Aparna Bhaduri and Meyers, {Jordan M.} and Xavier Rovira-Clav{\'e} and Hollmig, {S. Tyler} and Aasi, {Sumaira Z.} and Nolan, {Garry P.} and Joakim Lundeberg and Khavari, {Paul A.}",
note = "Funding Information: We thank members of the Khavari laboratory for helpful discussions and the National Genomics Infrastructure (NGI), Sweden and SNIC/UPPMAX for providing sequencing and computational infrastructure support, and Jamaica Jensen for histology support. This work was supported by the US Veterans Affairs Office of Research and Development I01BX00140908 (P.A.K.); National Institutes of Health (NIH) CA142635 and AR43799 (P.A.K.); 2U19AI057229-16 , 5P01HL10879707 , 5R01GM10983604 , 5R33CA18365403 , 5U01AI101984-07 , 5UH2AR06767604 , 5R01CA19665703 , 5U54CA20997103 , 5F99CA212231-02 , 1F32CA233203-01 , 5U01AI140498-02 , 1U54HG010426-01 , 5U19AI100627-07 , 1R01HL120724-01A1 , R33CA183692 , R01HL128173-04 , 5P01AI131374-02 , 5UG3DK114937-02 , 1U19AI135976-01 , IDIQ17X149 , 1U2CCA233238-01, and 1U2CCA233195-01 (G.P.N.); T32AR007422 (A.L.J.); Swedish Cancer Society (J.L.); Swedish Foundation for Strategic Research and the Swedish Research Council (J.L.); The Department of Defense ( W81XWH-14-1-0180 and W81XWH-12-1-0591 ) (G.P.N.); Food and Drug Administration ( HHSF223201610018C and DSTL/AGR00980 ) (G.P.N.); Cancer Research UK ( C27165/A29073 ) (G.P.N); The Bill and Melinda Gates Foundation ( OPP1113682 ) (G.P.N.); The Cancer Research Institute (G.P.N.); The Parker Institute for Cancer Immunotherapy (G.P.N.); Celgene ( 133826 and 134073 ) (G.P.N.); and the Rachford & Carlotta A. Harris Endowed Chair (G.P.N.). S.J. was supported by the Leukemia & Lymphoma Society Career Development Program and the Stanford Dean{\textquoteright}s Fellowship . Sequencing of scRNA-seq libraries was performed by the Stanford Functional Genomics Facility (supported by NIH grant S10OD018220 ). Publisher Copyright: {\textcopyright} 2020",
year = "2020",
doi = "10.1016/j.cell.2020.05.039",
language = "English",
journal = "Journal of Cleaner Production",
issn = "0959-6526",
publisher = "Elsevier Ltd.",
}