Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma

Andrew L. Ji, Adam J. Rubin, Kim Thrane, Sizun Jiang, David L. Reynolds, Robin M. Meyers, Margaret G. Guo, Benson M. George, Annelie Mollbrink, Joseph Bergenstråhle, Ludvig Larsson, Yunhao Bai, Bokai Zhu, Aparna Bhaduri, Jordan M. Meyers, Xavier Rovira-Clavé, S. Tyler Hollmig, Sumaira Z. Aasi, Garry P. Nolan, Joakim LundebergPaul A. Khavari

Research output: Contribution to journalArticlepeer-review

180 Scopus citations

Abstract

Integration of high-dimensional multi-omics approaches to characterize human cutaneous squamous cell carcinoma identifies a tumor-specific keratinocyte population as well as the immune infiltrates and heterogeneity at tumor leading edges.

Original languageEnglish
JournalJournal of Cleaner Production
DOIs
StateAccepted/In press - 2020
Externally publishedYes

Keywords

  • CRISPR screen
  • MIBI
  • intra-tumoral heterogeneity
  • multi-omics
  • scRNA-seq
  • skin cancer
  • spatial transcriptomics
  • squamous cell carcinoma
  • tumor immunology
  • tumor microenvironment

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