TY - JOUR
T1 - Multifocal hemorrhagic vasculopathy
T2 - Possibly a manifestation of central nervous system vasculitis
AU - Noskin, Olga
AU - Libman, Richard
AU - Mayer, Stephan
AU - Canoll, Peter
PY - 2006
Y1 - 2006
N2 - We report a patient with multiple spontaneous intracerebral hemorrhages involving cortical, subcortical, and deep brain structures. Despite extensive evaluation, no etiology was identified, and the possibility of primary central nervous system (CNS) vasculitis was entertained. Brain biopsy revealed small vessels with a lymphocytic infiltrate in brain tissue adjacent to hemorrhage. Despite this nonspecific finding, the patient appeared to respond to immunosuppressive therapy. In this report we review the various presentations of CNS vasculitis and suggest that this diagnosis be considered in the setting of multiple spontaneous intracerebral hemorrhages.
AB - We report a patient with multiple spontaneous intracerebral hemorrhages involving cortical, subcortical, and deep brain structures. Despite extensive evaluation, no etiology was identified, and the possibility of primary central nervous system (CNS) vasculitis was entertained. Brain biopsy revealed small vessels with a lymphocytic infiltrate in brain tissue adjacent to hemorrhage. Despite this nonspecific finding, the patient appeared to respond to immunosuppressive therapy. In this report we review the various presentations of CNS vasculitis and suggest that this diagnosis be considered in the setting of multiple spontaneous intracerebral hemorrhages.
KW - Brain biopsy
KW - CNS vasculitis
KW - Intracerebral hemorrhage
UR - http://www.scopus.com/inward/record.url?scp=30644480291&partnerID=8YFLogxK
U2 - 10.1016/j.jstrokecerebrovasdis.2005.09.002
DO - 10.1016/j.jstrokecerebrovasdis.2005.09.002
M3 - Article
AN - SCOPUS:30644480291
SN - 1052-3057
VL - 15
SP - 43
EP - 47
JO - Journal of Stroke and Cerebrovascular Diseases
JF - Journal of Stroke and Cerebrovascular Diseases
IS - 1
ER -