TY - JOUR
T1 - Multielemental bioimaging of tissues in children's environmental health research
AU - Austin, Christine
AU - Niedzwiecki, Megan M.
AU - Arora, Manish
N1 - Publisher Copyright:
Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Purpose of review: Metals play major roles in children's health and are associated with negative health outcomes via deficiency, overload, or toxicity. Constantly evolving analytical technology can provide new insight into how metal metabolism and exposure biology are intertwined in a range of biological matrices. Recent findings: Exposure can occur prenatally as many metals cross the placental barrier. The placenta is permeable to many metal species, some through tightly regulated transporters, and others because of a limited capacity for detoxification. Postbirth, metal exposure continues to exert long-term health effects, ranging from exposure to exogenous heavy metals, such as lead, to overload of otherwise essential metals, including manganese. Increasing evidence supports the existence of critical developmental windows when susceptibility to toxicants and nutritional deficiencies is highest. Elemental imaging technology provides microspatial information on metal uptake and retention across tissue architecture, which provides important insights into exposure and biologic response. Summary: Imaging the spatial distribution of elements, both essential and toxic, provides information that bulk measures cannot, including cell-specific distributions and timing of exposure.
AB - Purpose of review: Metals play major roles in children's health and are associated with negative health outcomes via deficiency, overload, or toxicity. Constantly evolving analytical technology can provide new insight into how metal metabolism and exposure biology are intertwined in a range of biological matrices. Recent findings: Exposure can occur prenatally as many metals cross the placental barrier. The placenta is permeable to many metal species, some through tightly regulated transporters, and others because of a limited capacity for detoxification. Postbirth, metal exposure continues to exert long-term health effects, ranging from exposure to exogenous heavy metals, such as lead, to overload of otherwise essential metals, including manganese. Increasing evidence supports the existence of critical developmental windows when susceptibility to toxicants and nutritional deficiencies is highest. Elemental imaging technology provides microspatial information on metal uptake and retention across tissue architecture, which provides important insights into exposure and biologic response. Summary: Imaging the spatial distribution of elements, both essential and toxic, provides information that bulk measures cannot, including cell-specific distributions and timing of exposure.
KW - elemental imaging
KW - environmental exposure
KW - metals
KW - placenta
UR - http://www.scopus.com/inward/record.url?scp=84960448394&partnerID=8YFLogxK
U2 - 10.1097/MOP.0000000000000328
DO - 10.1097/MOP.0000000000000328
M3 - Review article
C2 - 26845145
AN - SCOPUS:84960448394
SN - 1040-8703
VL - 28
SP - 216
EP - 220
JO - Current Opinion in Pediatrics
JF - Current Opinion in Pediatrics
IS - 2
ER -