TY - JOUR
T1 - Multidetector-row computed tomography and magnetic resonance imaging of atherosclerotic lesions in human ex vivo coronary arteries
AU - Nikolaou, Konstantin
AU - Becker, Christoph R.
AU - Muders, Michael
AU - Babaryka, Gregor
AU - Scheidler, Juergen
AU - Flohr, Thomas
AU - Loehrs, Udo
AU - Reiser, Maximilian F.
AU - Fayad, Zahi A.
PY - 2004/6
Y1 - 2004/6
N2 - In the present study, we tested the ability of multidetector-row computed tomography (MDCT) and magnetic resonance imaging (MRI) to identify and retrospectively characterize atherosclerotic lesions in human ex vivo coronary arteries. Thirteen ex vivo hearts were studied with MDCT and MRI. MDCT-images were obtained with an isotropic voxel size of 0.6 mm3. MR images were obtained with an in-plane resolution of 195 μm and 3 mm slice thickness. All images were matched with histopathology sections. For both modalities, the sensitivity for the detection of any atherosclerotic lesion was evaluated, and a retrospective analysis of plaque morphology according to criteria defined by the American Heart Association (AHA) was performed. At histopathology, 28 atherosclerotic lesions were found. 21 and 23 of these lesions were identified by MDCT and MRI, respectively. Both modalities detected a small number of false-positive lesions. After retrospective matching with histopathology, MDCT as well as MRI were able to differentiate typical morpholocigal features for fatty, fibrous or calcified plaque components. Using the information presented in this study, in vivo coronary artery wall imaging using MDCT as well as MRI could be facilitated and supported for future investigations on this subject.
AB - In the present study, we tested the ability of multidetector-row computed tomography (MDCT) and magnetic resonance imaging (MRI) to identify and retrospectively characterize atherosclerotic lesions in human ex vivo coronary arteries. Thirteen ex vivo hearts were studied with MDCT and MRI. MDCT-images were obtained with an isotropic voxel size of 0.6 mm3. MR images were obtained with an in-plane resolution of 195 μm and 3 mm slice thickness. All images were matched with histopathology sections. For both modalities, the sensitivity for the detection of any atherosclerotic lesion was evaluated, and a retrospective analysis of plaque morphology according to criteria defined by the American Heart Association (AHA) was performed. At histopathology, 28 atherosclerotic lesions were found. 21 and 23 of these lesions were identified by MDCT and MRI, respectively. Both modalities detected a small number of false-positive lesions. After retrospective matching with histopathology, MDCT as well as MRI were able to differentiate typical morpholocigal features for fatty, fibrous or calcified plaque components. Using the information presented in this study, in vivo coronary artery wall imaging using MDCT as well as MRI could be facilitated and supported for future investigations on this subject.
KW - Computed tomography
KW - Coronary artery disease
KW - Histopathology
KW - Magnetic resonance imaging
KW - Plaque imaging
UR - http://www.scopus.com/inward/record.url?scp=2342638270&partnerID=8YFLogxK
U2 - 10.1016/j.atherosclerosis.2004.01.041
DO - 10.1016/j.atherosclerosis.2004.01.041
M3 - Article
C2 - 15136054
AN - SCOPUS:2342638270
SN - 0021-9150
VL - 174
SP - 243
EP - 252
JO - Atherosclerosis
JF - Atherosclerosis
IS - 2
ER -