Multicentric Castleman disease in an HHV-8-infected child born to consanguineous parents

Sandrine Leroy; Despina Moshous; Olivier Cassar; Yves Reguerre; Minji Byun; Vincent Pedergnana; Danielle Canioni; Antoine Gessain; Eric Oksenhendler; Claire Fieschi; Nizar Mahlaoui; Jean Pierre Rivière; Rose Marie Herbigneaux; Matthias Muszlak; Jean Pierre Arnaud; Alain Fischer; Capucine Picard; Stéphane Blanche; Sabine Plancoulaine; Jean Laurent Casanova

doi:10.1542/peds.2010-2739

Multicentric Castleman disease in an HHV-8-infected child born to consanguineous parents

Sandrine Leroy, Despina Moshous, Olivier Cassar, Yves Reguerre, Minji Byun, Vincent Pedergnana, Danielle Canioni, Antoine Gessain, Eric Oksenhendler, Claire Fieschi, Nizar Mahlaoui, Jean Pierre Rivière, Rose Marie Herbigneaux, Matthias Muszlak, Jean Pierre Arnaud, Alain Fischer, Capucine Picard, Stéphane Blanche, Sabine Plancoulaine, Jean Laurent Casanova

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20 Scopus citations

Abstract

Childhood multicentric Castleman disease (MCD) is a rare and unexplained lymphoproliferative disorder. We report a human herpesvirus- 8 (HHV-8)-infected child, born to consanguineous Comorian parents, who displayed isolated MCD in the absence of any known immunodeficiency. We also systematically review the clinical features of the 32 children previously reported with isolated and unexplained MCD. The characteristics of this patient and the geographic areas of origin of most previous cases suggest that pediatric MCD is associated with HHV-8 infection. Moreover, as previously suggested for Kaposi sarcoma, MCD in childhood may result from inborn errors of immunity to HHV-8 infection.

Original language	English
Pages (from-to)	e199-e203
Journal	Pediatrics
Volume	129
Issue number	1
DOIs	https://doi.org/10.1542/peds.2010-2739
State	Published - Jan 2012
Externally published	Yes

Keywords

Children
Human herpes virus 8
Multicentric castleman disease
Systematic review

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10.1542/peds.2010-2739

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Leroy, S., Moshous, D., Cassar, O., Reguerre, Y., Byun, M., Pedergnana, V., Canioni, D., Gessain, A., Oksenhendler, E., Fieschi, C., Mahlaoui, N., Rivière, J. P., Herbigneaux, R. M., Muszlak, M., Arnaud, J. P., Fischer, A., Picard, C., Blanche, S., Plancoulaine, S., & Casanova, J. L. (2012). Multicentric Castleman disease in an HHV-8-infected child born to consanguineous parents. Pediatrics, 129(1), e199-e203. https://doi.org/10.1542/peds.2010-2739

@article{8214b3da91b44cc49cfef895c48e8137,

title = "Multicentric Castleman disease in an HHV-8-infected child born to consanguineous parents",

abstract = "Childhood multicentric Castleman disease (MCD) is a rare and unexplained lymphoproliferative disorder. We report a human herpesvirus- 8 (HHV-8)-infected child, born to consanguineous Comorian parents, who displayed isolated MCD in the absence of any known immunodeficiency. We also systematically review the clinical features of the 32 children previously reported with isolated and unexplained MCD. The characteristics of this patient and the geographic areas of origin of most previous cases suggest that pediatric MCD is associated with HHV-8 infection. Moreover, as previously suggested for Kaposi sarcoma, MCD in childhood may result from inborn errors of immunity to HHV-8 infection.",

keywords = "Children, Human herpes virus 8, Multicentric castleman disease, Systematic review",

author = "Sandrine Leroy and Despina Moshous and Olivier Cassar and Yves Reguerre and Minji Byun and Vincent Pedergnana and Danielle Canioni and Antoine Gessain and Eric Oksenhendler and Claire Fieschi and Nizar Mahlaoui and Rivi{\`e}re, {Jean Pierre} and Herbigneaux, {Rose Marie} and Matthias Muszlak and Arnaud, {Jean Pierre} and Alain Fischer and Capucine Picard and St{\'e}phane Blanche and Sabine Plancoulaine and Casanova, {Jean Laurent}",

year = "2012",

month = jan,

doi = "10.1542/peds.2010-2739",

language = "English",

volume = "129",

pages = "e199--e203",

journal = "Pediatrics",

issn = "0031-4005",

publisher = "American Academy of Pediatrics",

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Leroy, S, Moshous, D, Cassar, O, Reguerre, Y, Byun, M, Pedergnana, V, Canioni, D, Gessain, A, Oksenhendler, E, Fieschi, C, Mahlaoui, N, Rivière, JP, Herbigneaux, RM, Muszlak, M, Arnaud, JP, Fischer, A, Picard, C, Blanche, S, Plancoulaine, S & Casanova, JL 2012, 'Multicentric Castleman disease in an HHV-8-infected child born to consanguineous parents', Pediatrics, vol. 129, no. 1, pp. e199-e203. https://doi.org/10.1542/peds.2010-2739

TY - JOUR

T1 - Multicentric Castleman disease in an HHV-8-infected child born to consanguineous parents

AU - Leroy, Sandrine

AU - Moshous, Despina

AU - Cassar, Olivier

AU - Reguerre, Yves

AU - Byun, Minji

AU - Pedergnana, Vincent

AU - Canioni, Danielle

AU - Gessain, Antoine

AU - Oksenhendler, Eric

AU - Fieschi, Claire

AU - Mahlaoui, Nizar

AU - Rivière, Jean Pierre

AU - Herbigneaux, Rose Marie

AU - Muszlak, Matthias

AU - Arnaud, Jean Pierre

AU - Fischer, Alain

AU - Picard, Capucine

AU - Blanche, Stéphane

AU - Plancoulaine, Sabine

AU - Casanova, Jean Laurent

PY - 2012/1

Y1 - 2012/1

N2 - Childhood multicentric Castleman disease (MCD) is a rare and unexplained lymphoproliferative disorder. We report a human herpesvirus- 8 (HHV-8)-infected child, born to consanguineous Comorian parents, who displayed isolated MCD in the absence of any known immunodeficiency. We also systematically review the clinical features of the 32 children previously reported with isolated and unexplained MCD. The characteristics of this patient and the geographic areas of origin of most previous cases suggest that pediatric MCD is associated with HHV-8 infection. Moreover, as previously suggested for Kaposi sarcoma, MCD in childhood may result from inborn errors of immunity to HHV-8 infection.

AB - Childhood multicentric Castleman disease (MCD) is a rare and unexplained lymphoproliferative disorder. We report a human herpesvirus- 8 (HHV-8)-infected child, born to consanguineous Comorian parents, who displayed isolated MCD in the absence of any known immunodeficiency. We also systematically review the clinical features of the 32 children previously reported with isolated and unexplained MCD. The characteristics of this patient and the geographic areas of origin of most previous cases suggest that pediatric MCD is associated with HHV-8 infection. Moreover, as previously suggested for Kaposi sarcoma, MCD in childhood may result from inborn errors of immunity to HHV-8 infection.

KW - Children

KW - Human herpes virus 8

KW - Multicentric castleman disease

KW - Systematic review

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DO - 10.1542/peds.2010-2739

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AN - SCOPUS:84855286868

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VL - 129

SP - e199-e203

JO - Pediatrics

JF - Pediatrics

IS - 1

ER -

Multicentric Castleman disease in an HHV-8-infected child born to consanguineous parents

Abstract

Keywords

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