Multi-tissue computational modeling analyzes pathophysiology of type 2 diabetes in MKR mice

Agriculture & Biology

• animal models 7%
• beta oxidation 29%
• biochemical pathways 14%
• branched chain amino acids 43%
• degradation 15%
• free fatty acids 7%
• gene expression 10%
• genome 4%
• lipids 4%
• liver 5%
• metabolic diseases 10%
• mice 45%
• microarray technology 9%
• model validation 11%
• muscles 5%
• noninsulin-dependent diabetes mellitus 100%
• pathophysiology 95%
• testing 3%
• tissues 34%

Chemical Compounds

• Amount 4%
• Branched-Chain Amino Acid 64%
• Disorder 9%
• Fat 11%
• Fatty Acid 27%
• Metabolic 63%
• Microarrays 36%
• Oxidation Reaction 15%
• Plasma 6%
• Simulation 7%

Medicine & Life Sciences

• Branched Chain Amino Acids 45%
• Computer Simulation 8%
• Costs and Cost Analysis 5%
• Down-Regulation 12%
• Fats 6%
• Fatty Acids 22%
• Gene Expression 10%
• Genome 5%
• Liver 4%
• Metabolic Networks and Pathways 17%
• Microarray Analysis 8%
• Muscles 5%
• Nonesterified Fatty Acids 9%
• Type 2 Diabetes Mellitus 59%