Multi-timepoint imaging with PSMA-targeted [18F]F-Florastamin PET/CT: lesion detection and comparison to conventional imaging

Sara Sheikhbahaei, Ricardo Bello Martinez, Mark C. Markowski, Mario A. Eisenberger, Kenneth J. Pienta, Diane Reyes, Mary Katherine Brosnan, Ergi Spiro, Rehab AbdAllah, Daniel P. Holt, Robert F. Dannals, Rudolf A. Werner, Martin G. Pomper, Michael A. Gorin, Lilja B. Solnes, Steven P. Rowe

Research output: Contribution to journalArticlepeer-review


Objective: The aims of this study were to investigate the utility of [18F]F-Florastamin, a novel prostate-specific membrane antigen (PSMA)-targeted PET radiotracer with facile radiochemistry, relative to the conventional imaging for the detection of sties of disease and evaluate the effect of multi-timepoint imaging with [18F]F-Florastamin PET on lesion detectability. Methods: Eight prostate cancer patients with known or suspected recurrence who underwent [18F]F-Florastamin PET/CT at 1-h and 2-h imaging time-points were included in this prospective pilot study. [18F]F-Florastamin PET images were interpreted visually and quantitatively at both time points and compared with CIM. Results: [18F]F-Florastamin PET was superior to CT in the detection of active osseous metastases and small-sized metastatic lymph nodes that do not fall under the anatomic imaging size criteria for metastasis. Multi-timepoint imaging showed a significant reduction in the blood pool, bone marrow and muscular uptake, and increase in liver uptake over time. There is a significant improvement in tumor-to-background ratio (TBR) at the 2-h imaging time-point (P = 0.04). The mean percentage change in TBR at 2-h was 21% (SD = 0.31). Conclusions: [18F]F-Florastamin is a promising new radioligand for PSMA-targeted PET with suitable lesion detectability and high TBR at both time points.

Original languageEnglish
Pages (from-to)246-254
Number of pages9
JournalAnnals of Nuclear Medicine
Issue number4
StatePublished - Apr 2023


  • Multi-time point imaging
  • Prostate cancer
  • Prostate-specific membrane antigen PET/CT
  • [F]F-Florastamin


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