Muir-Torre syndrome appropriate use criteria: Effect of patient age on appropriate use scores

Task Force/Committee Members, Rating Panel

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Background: Muir-Torre syndrome (MTS) is a rare inherited syndrome, with an increased risk of sebaceous and visceral malignancy. Prior reports suggest screening for mismatch repair (MMR) deficiency may be warranted in patients <50 years and when sebaceous neoplasms are located on a non-head and neck location. Previously, appropriate use criteria (AUC) were developed for clinical scenarios in patients >60 years concerning the use of MMR protein immunohistochemistry (MMRP-IHC). This analysis explores the appropriateness of testing in patients ≤60 years. Methods: Panel raters from the AUC Task Force rated the use of MMRP-IHC testing for MTS for previously rated scenarios with the only difference being age. Results: Results verify the previously developed AUC for the use of MMRP-IHC in neoplasms associated with MTS in patients >60 years. Results also show that in patients ≤60 years with a single sebaceous tumor on a non-head and neck site, MMRP-IHC testing should be considered. Testing can also be considered with a 2-antibody panel on periocular sebaceous carcinoma in younger patients. Conclusions: Our findings align with known evidence supporting the need to incorporate clinical parameters in identifying patients at risk for MTS, with age being a factor when considering MMRP-IHC testing.

Original languageEnglish
Pages (from-to)484-489
Number of pages6
JournalJournal of Cutaneous Pathology
Issue number7
StatePublished - Jul 2019
Externally publishedYes


  • Muir-Torre syndrome
  • anatomic location
  • appropriate use criteria
  • expert rating
  • immunohistochemistry
  • mismatch repair protein analysis
  • patient age
  • sebaceous neoplasms


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