Mucosal IgG in inflammatory bowel disease - a question of (sub)class?

Tomas Castro-Dopico, Menna R. Clatworthy

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Immunoglobulins (Igs) form a cornerstone of mucosal immunity. In the gastrointestinal tract, secretory IgA and IgM bind to commensal microorganisms within the intestinal lumen to prevent them from breaching the intestinal epithelium - a process known as immune exclusion. In recent years, there has been renewed interest in the role of IgG in intestinal immunity, driven in part by a genetic association of an affinity-lowering variant of an IgG receptor, FcγRIIA, with protection from ulcerative colitis (UC), a subclass of inflammatory bowel disease (IBD). We recently demonstrated a role for IgG and Fcγ receptor signalling in driving pathogenic IL-1β production by colonic mononuclear phagocytes and the subsequent induction of a local type 17 response in UC. Here, we discuss the potential relevance of our observations to the other major subclass of IBD - Crohn's disease (CD) - where the genetic association with FCGR variants is less robust and consider how this may impact therapeutic interventions in these disease subsets.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalGut Microbes
Volume12
Issue number1
DOIs
StatePublished - 9 Nov 2020
Externally publishedYes

Keywords

  • Crohn’s disease
  • Fcγ receptors
  • IgG
  • inflammatory bowel disease
  • subclasses
  • ulcerative colitis

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