Mucosal epithelium in health and disease

Prashant P. Ponda, Lloyd Mayer

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

The intestinal epithelium has emerged as one of the links between the innate and adaptive immune systems. Novel roles have been elucidated for its participation in antigen uptake and presentation, costimulatory signaling, and intestinal homeostasis. Its concomitant interaction with immune cells and commensal flora demonstrates the epithelium's multifaceted responsibility in protecting against intestinal pathology while maintaining immune competence. Its functional capacity is now more clearly defined in disease states such as celiac disease, Crohn's disease, and ulcerative colitis and in maintaining intestinal integrity through toll-like receptor signaling pathways.

Original languageEnglish
Pages (from-to)549-556
Number of pages8
JournalCurrent Molecular Medicine
Volume5
Issue number6
DOIs
StatePublished - Sep 2005

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