Mucoprotein content of cerebro-spinal fluid

Allen Silverstein, Ezra M. Greenspan

Research output: Contribution to journalArticlepeer-review


(1) Many of the studies of CSF protein fraction determination and the differences between serum and CSF proteins as published in the English language were reviewed. Although high gamma-globulin levels in the CSF of patients with multiple sclerosis and neuro-syphilis are frequently observed, the practical value of these tests remains limited. (2) Mucoprotein a special protein carbohydrate complex of proven clinical significance in the serum - was detected by a simple laboratory technique in about 1/3 of the 120 CSF’s obtained from neurological and non-neurological patients. (3) CSF mucoprotein was detected more often in the male sex. No definite correlation could be established between the presence of CSF mucoprotein and the total CSF protein, size of the ventricular system, or age of the patients studied. (4) Although there appeared to be a higher incidence of CSF muco- protein in patients with CNS neoplasms and proven occlusive vascular disease, the findings of mucoprotein in the CSF of patients without neurological disease (in the same frequency and quantities as in patients with neurological disease) appeared to limit any potential diagnostic significance of CSF mucoprotein investigations at the present time.

Original languageEnglish
Pages (from-to)306-318
Number of pages13
JournalStereotactic and Functional Neurosurgery
Issue number4
StatePublished - 1959


Dive into the research topics of 'Mucoprotein content of cerebro-spinal fluid'. Together they form a unique fingerprint.

Cite this