MSH and MIF-I in animal models of tardive dyskinesia

Kenneth L. Davis; Abba J. Kastin; Barbara A. Beilstein; Adela L. Vento

doi:10.1016/0091-3057(80)90117-3

MSH and MIF-I in animal models of tardive dyskinesia

Kenneth L. Davis
, Abba J. Kastin
, Barbara A. Beilstein
, Adela L. Vento

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

α-Melanocyte stimulating hormone (MSH) and MSH release inhibiting factor (MIF-I) were tested for their effects on animals with prior exposure to haloperidol. Such animals are known to have an augmented stereotypic response to dopamine agonist and have been used as an animal model of tardive dyskinesia. Both MSH and MIF-I increased the stereotypy that followed the administration of the lowest dose of apomorphine (0.125 mg/kg), suggesting that MSH and MIF-I might weakly increase dopaminergic transmission.

Original language	English
Pages (from-to)	37-40
Number of pages	4
Journal	Pharmacology, Biochemistry and Behavior
Volume	13
Issue number	1
DOIs	https://doi.org/10.1016/0091-3057(80)90117-3
State	Published - Jul 1980
Externally published	Yes

Keywords

Apomorphine
Autoreceptor
MSH release inhibiting factor (MIF)
Tardive dyskinesia
α-melanocyte-stimulating hormone (MSH)

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10.1016/0091-3057(80)90117-3

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title = "MSH and MIF-I in animal models of tardive dyskinesia",

abstract = "α-Melanocyte stimulating hormone (MSH) and MSH release inhibiting factor (MIF-I) were tested for their effects on animals with prior exposure to haloperidol. Such animals are known to have an augmented stereotypic response to dopamine agonist and have been used as an animal model of tardive dyskinesia. Both MSH and MIF-I increased the stereotypy that followed the administration of the lowest dose of apomorphine (0.125 mg/kg), suggesting that MSH and MIF-I might weakly increase dopaminergic transmission.",

keywords = "Apomorphine, Autoreceptor, MSH release inhibiting factor (MIF), Tardive dyskinesia, α-melanocyte-stimulating hormone (MSH)",

author = "Davis, \{Kenneth L.\} and Kastin, \{Abba J.\} and Beilstein, \{Barbara A.\} and Vento, \{Adela L.\}",

year = "1980",

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language = "English",

volume = "13",

pages = "37--40",

journal = "Pharmacology, Biochemistry and Behavior",

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T1 - MSH and MIF-I in animal models of tardive dyskinesia

AU - Davis, Kenneth L.

AU - Kastin, Abba J.

AU - Beilstein, Barbara A.

AU - Vento, Adela L.

PY - 1980/7

Y1 - 1980/7

N2 - α-Melanocyte stimulating hormone (MSH) and MSH release inhibiting factor (MIF-I) were tested for their effects on animals with prior exposure to haloperidol. Such animals are known to have an augmented stereotypic response to dopamine agonist and have been used as an animal model of tardive dyskinesia. Both MSH and MIF-I increased the stereotypy that followed the administration of the lowest dose of apomorphine (0.125 mg/kg), suggesting that MSH and MIF-I might weakly increase dopaminergic transmission.

AB - α-Melanocyte stimulating hormone (MSH) and MSH release inhibiting factor (MIF-I) were tested for their effects on animals with prior exposure to haloperidol. Such animals are known to have an augmented stereotypic response to dopamine agonist and have been used as an animal model of tardive dyskinesia. Both MSH and MIF-I increased the stereotypy that followed the administration of the lowest dose of apomorphine (0.125 mg/kg), suggesting that MSH and MIF-I might weakly increase dopaminergic transmission.

KW - Apomorphine

KW - Autoreceptor

KW - MSH release inhibiting factor (MIF)

KW - Tardive dyskinesia

KW - α-melanocyte-stimulating hormone (MSH)

UR - https://www.scopus.com/pages/publications/0018965922

U2 - 10.1016/0091-3057(80)90117-3

DO - 10.1016/0091-3057(80)90117-3

M3 - Article

C2 - 6105677

AN - SCOPUS:0018965922

SN - 0091-3057

VL - 13

SP - 37

EP - 40

JO - Pharmacology, Biochemistry and Behavior

JF - Pharmacology, Biochemistry and Behavior

IS - 1

ER -

MSH and MIF-I in animal models of tardive dyskinesia

Abstract

Keywords

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