mRNA regulation by Puf domain proteins.

Robin P. Wharton; Aneel K. Aggarwal

doi:10.1126/stke.3542006pe37

mRNA regulation by Puf domain proteins.

Robin P. Wharton, Aneel K. Aggarwal

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Puf domain proteins bind specific sequences in mRNAs to regulate their translation or stability, or both. Neither the mechanism of their action nor the identities of targeted mRNAs have been well defined. Recent work suggests that Puf proteins generally act by recruiting Pop2, a deadenylation enzyme that is part of a large complex. Recent work from a separate group defines a subset of the Drosophila transcriptome that is bound by the fly Puf protein, Pumilio. Together, these papers substantially increase our understanding of the biology of the Puf family of mRNA regulators.

Original language	English
Pages (from-to)	pe37
Journal	Science's STKE : signal transduction knowledge environment
Volume	2006
Issue number	354
DOIs	https://doi.org/10.1126/stke.3542006pe37
State	Published - 2006
Externally published	Yes

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mRNA regulation by Puf domain proteins.

Abstract

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