TY - JOUR
T1 - mRNA delivery in cancer immunotherapy
AU - Zhong, Yichen
AU - Du, Shi
AU - Dong, Yizhou
N1 - Publisher Copyright:
© 2023 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences
PY - 2023/4
Y1 - 2023/4
N2 - Messenger RNA (mRNA) has drawn much attention in the medical field. Through various treatment approaches including protein replacement therapies, gene editing, and cell engineering, mRNA is becoming a potential therapeutic strategy for cancers. However, delivery of mRNA into targeted organs and cells can be challenging due to the unstable nature of its naked form and the low cellular uptake. Therefore, in addition to mRNA modification, efforts have been devoted to developing nanoparticles for mRNA delivery. In this review, we introduce four categories of nanoparticle platform systems: lipid, polymer, lipid-polymer hybrid, and protein/peptide-mediated nanoparticles, together with their roles in facilitating mRNA-based cancer immunotherapies. We also highlight promising treatment regimens and their clinical translation.
AB - Messenger RNA (mRNA) has drawn much attention in the medical field. Through various treatment approaches including protein replacement therapies, gene editing, and cell engineering, mRNA is becoming a potential therapeutic strategy for cancers. However, delivery of mRNA into targeted organs and cells can be challenging due to the unstable nature of its naked form and the low cellular uptake. Therefore, in addition to mRNA modification, efforts have been devoted to developing nanoparticles for mRNA delivery. In this review, we introduce four categories of nanoparticle platform systems: lipid, polymer, lipid-polymer hybrid, and protein/peptide-mediated nanoparticles, together with their roles in facilitating mRNA-based cancer immunotherapies. We also highlight promising treatment regimens and their clinical translation.
KW - Cancer immunotherapy
KW - Lipid nanoparticles
KW - Lipid–polymer hybrid nanoparticles
KW - Messenger RNA
KW - Polymeric nanoparticles
KW - Protein/peptide-mediated nanoparticles
KW - mRNA delivery
UR - http://www.scopus.com/inward/record.url?scp=85150374515&partnerID=8YFLogxK
U2 - 10.1016/j.apsb.2023.03.001
DO - 10.1016/j.apsb.2023.03.001
M3 - Review article
AN - SCOPUS:85150374515
SN - 2211-3835
VL - 13
SP - 1348
EP - 1357
JO - Acta Pharmaceutica Sinica B
JF - Acta Pharmaceutica Sinica B
IS - 4
ER -