mRNA-1273 vaccine-induced antibodies maintain Fc effector functions across SARS-CoV-2 variants of concern

Paulina Kaplonek, Stephanie Fischinger, Deniz Cizmeci, Yannic C. Bartsch, Jaewon Kang, John S. Burke, Sally A. Shin, Diana Dayal, Patrick Martin, Colin Mann, Fatima Amanat, Boris Julg, Eric J. Nilles, Elon R. Musk, Anil S. Menon, Florian Krammer, Erica Ollman Saphire, Carfi Andrea Carfi, Galit Alter

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

SARS-CoV-2 mRNA vaccines confer robust protection against COVID-19, but the emergence of variants has generated concerns regarding the protective efficacy of the currently approved vaccines, which lose neutralizing potency against some variants. Emerging data suggest that antibody functions beyond neutralization may contribute to protection from the disease, but little is known about SARS-CoV-2 antibody effector functions. Here, we profiled the binding and functional capacity of convalescent antibodies and Moderna mRNA-1273 COVID-19 vaccine-induced antibodies across SARS-CoV-2 variants of concern (VOCs). Although the neutralizing responses to VOCs decreased in both groups, the Fc-mediated responses were distinct. In convalescent individuals, although antibodies exhibited robust binding to VOCs, they showed compromised interactions with Fc-receptors. Conversely, vaccine-induced antibodies also bound robustly to VOCs but continued to interact with Fc-receptors and mediate antibody effector functions. These data point to a resilience in the mRNA-vaccine-induced humoral immune response that may continue to offer protection from SARS-CoV-2 VOCs independent of neutralization.

Original languageEnglish
Pages (from-to)355-365.e4
JournalImmunity
Volume55
Issue number2
DOIs
StatePublished - 8 Feb 2022

Keywords

  • COVID-19
  • Fc effector function
  • SARS-CoV-2
  • mRNA-1273 vaccination
  • vaccines
  • variants of concern

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