TY - JOUR
T1 - MRI-measured pelvic bone marrow adipose tissue is inversely related to DXA-measured bone mineral in younger and older adults
AU - Shen, W.
AU - Chen, J.
AU - Gantz, M.
AU - Punyanitya, M.
AU - Heymsfield, S. B.
AU - Gallagher, D.
AU - Albu, J.
AU - Engelson, E.
AU - Kotler, D.
AU - Pi-Sunyer, X.
AU - Gilsanz, V.
N1 - Funding Information:
The project described was supported by Award Number R21DK082937 from the National Institute Of Diabetes and Digestive and Kidney Diseases, United States. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute Of Diabetes and Digestive and Kidney Diseases or the National Institutes of Health. The project was also supported by National Institutes of Health Grants R01 DK40414, R01 DK42618, and P30 DK26687, R29-AG14715, F32-AG05679, M01 RR00645, UL1 RR024156.
PY - 2012/9
Y1 - 2012/9
N2 - Background/Objectives:Recent research has shown an inverse relationship between bone marrow adipose tissue (BMAT) and bone mineral density (BMD). There is a lack of evidence at the macro-imaging level to establish whether increased BMAT is a cause or effect of bone loss. This cross-sectional study compared the BMAT and BMD relationship between a younger adult group at or approaching peak bone mass (PBM; age 18.0-39.9 years) and an older group with potential bone loss (PoBL; age 40.0-88.0 years). Subjects/Methods:Pelvic BMAT was evaluated in 560 healthy men and women with T1-weighted whole-body magnetic resonance imaging. BMD was measured using whole-body dual-energy X-ray absorptiometry.Results:An inverse correlation was observed between pelvic BMAT and pelvic, total and spine BMD in the younger PBM group (r0.419 to 0.461, P0.001) and in the older PoBL group (r0.405 to 0.500, P0.001). After adjusting for age, sex, ethnicity, menopausal status, total body fat, skeletal muscle, subcutaneous and visceral adipose tissue, neither subject group (younger PBM vs older PoBL) nor its interaction with pelvic BMAT significantly contributed to the regression models with BMD as dependent variable and pelvic BMAT as independent variable (P0.434-0.928).Conclusions:Our findings indicate that an inverse relationship between pelvic BMAT and BMD is present both in younger subjects who have not yet experienced bone loss and also in older subjects. These results provide support at the macro-imaging level for the hypothesis that low BMD may be a result of preferential differentiation of mesenchymal stem cells from osteoblasts to adipocytes.
AB - Background/Objectives:Recent research has shown an inverse relationship between bone marrow adipose tissue (BMAT) and bone mineral density (BMD). There is a lack of evidence at the macro-imaging level to establish whether increased BMAT is a cause or effect of bone loss. This cross-sectional study compared the BMAT and BMD relationship between a younger adult group at or approaching peak bone mass (PBM; age 18.0-39.9 years) and an older group with potential bone loss (PoBL; age 40.0-88.0 years). Subjects/Methods:Pelvic BMAT was evaluated in 560 healthy men and women with T1-weighted whole-body magnetic resonance imaging. BMD was measured using whole-body dual-energy X-ray absorptiometry.Results:An inverse correlation was observed between pelvic BMAT and pelvic, total and spine BMD in the younger PBM group (r0.419 to 0.461, P0.001) and in the older PoBL group (r0.405 to 0.500, P0.001). After adjusting for age, sex, ethnicity, menopausal status, total body fat, skeletal muscle, subcutaneous and visceral adipose tissue, neither subject group (younger PBM vs older PoBL) nor its interaction with pelvic BMAT significantly contributed to the regression models with BMD as dependent variable and pelvic BMAT as independent variable (P0.434-0.928).Conclusions:Our findings indicate that an inverse relationship between pelvic BMAT and BMD is present both in younger subjects who have not yet experienced bone loss and also in older subjects. These results provide support at the macro-imaging level for the hypothesis that low BMD may be a result of preferential differentiation of mesenchymal stem cells from osteoblasts to adipocytes.
KW - aging
KW - body composition
KW - bone marrow adipose tissue
KW - bone mineral density
KW - dual-energy X-ray absorptiometry
KW - magnetic resonance imaging
UR - https://www.scopus.com/pages/publications/84865990349
U2 - 10.1038/ejcn.2012.35
DO - 10.1038/ejcn.2012.35
M3 - Article
C2 - 22491495
AN - SCOPUS:84865990349
SN - 0954-3007
VL - 66
SP - 983
EP - 988
JO - European Journal of Clinical Nutrition
JF - European Journal of Clinical Nutrition
IS - 9
ER -