MRI Features of Free Liquid Silicone in the Transgender Female Breast

Emily B. Sonnenblick, Shivani Chaudhry, Karen A. Lee, Shabnam Jaffer, Frank Fang, Jess Ting, Laurie R. Margolies

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Objective: To define MRI features of free liquid silicone injection (FLSI) of the breast in transgender women considering surgical management. Methods: This study was IRB-Approved. MRI images from transgender women with FLSI imaged between 2009 and 2019 were reviewed. Presence and location of fibrotic masses (FMs) in the breast(s) and pectoralis muscle and patterns of granulomas were correlated with clinicopathologic findings. Background enhancement was quantified. Comparisons were performed using two-Tailed Fisher exact and Student's t test. Results: Of 21 transgender women with FLSI (mean age 46.8 years), 13/21 (61.9%) had a dominant FM measuring over 4 cm; these were limited to breast and pectoralis in 6/21 (28.6%), breast in 9/21 (42.9%), and pectoralis only in 2/21 (9.5%). Four of 21 patients (19.0%) had no FMs, and 4/21 (19.0%) had masses under 4 cm. Mean size of the dominant FM was 7.4 cm (range 4-12 cm). FMs were enhancing in 5/13 (38.5%) and contained T2 high signal granulomas in 8/13 (61.5%). While 18/21 (85.8%) of cases showed mild to moderate overall background enhancement, the majority 7/13 (61.5%) of dominant FM were non-enhancing. About half of cases (11/21, 52.4%) had diffuse foci, and half (10/21, 47.6%) had diffuse foci and masses throughout the breast and pectoralis muscle. These foci and masses displayed T2 high signal in 13/21 (61.9%). There were no occult carcinomas observed. Conclusion: MRI performed on symptomatic FLSI patients considering surgical treatment is helpful in assessing the extent of silicone infiltration and fibrotic reaction of the breast and pectoralis muscle.

Original languageEnglish
Pages (from-to)322-331
Number of pages10
JournalJournal of Breast Imaging
Issue number3
StatePublished - 1 May 2021


  • MRI
  • breast
  • free liquid silicone
  • transgender


Dive into the research topics of 'MRI Features of Free Liquid Silicone in the Transgender Female Breast'. Together they form a unique fingerprint.

Cite this