MRI correlates of disability in African-Americans with multiple sclerosis

Jonathan Howard, Marco Battaglini, James Scott Babb, Donatello Arienzo, Brigitte Holst, Mirza Omari, Nicola de Stefano, Joseph Herbert, Matilde Inglese

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32 Scopus citations

Abstract

Objectives: Multiple sclerosis (MS) in African-Americans (AAs) is characterized by more rapid disease progression and poorer response to treatment than in Caucasian-Americans (CAs). MRI provides useful and non-invasive tools to investigate the pathological substrate of clinical progression. The aim of our study was to compare MRI measures of brain damage between AAs and CAs with MS. Methods: Retrospective analysis of 97 AAs and 97 CAs with MS matched for age, gender, disease duration and age at MRI examination. Results: AA patients had significantly greater T2- (p = 0.001) and T1-weighted (p = 0.0003) lesion volumes compared to CA patients. In contrast, measurements of global and regional brain volume did not significantly differ between the two ethnic groups (p>0.1). Conclusions: By studying a quite large sample of well demographically and clinically matched CA and AA patients with a homogeneous MRI protocol we showed that higher lesion accumulation, rather than pronounced brain volume decrease might explain the early progress to ambulatory assistance of AAs with MS.

Original languageEnglish
Article numbere43061
JournalPLoS ONE
Volume7
Issue number8
DOIs
StatePublished - 10 Aug 2012

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