TY - JOUR
T1 - MRI assessment of lean and adipose tissue distribution in female patients with Cushing's disease
AU - Geer, Eliza B.
AU - Shen, Wei
AU - Gallagher, Dympna
AU - Punyanitya, Mark
AU - Looker, Helen C.
AU - Post, Kalmon D.
AU - Freda, Pamela U.
PY - 2010/10
Y1 - 2010/10
N2 - Objective Chronic hypercortisolemia due to Cushing's disease (CD) results in abnormal adipose tissue (AT) distribution. Whole-body magnetic resonance imaging (MRI) was used to examine lean and AT distribution in female patients with CD to further understand the role of glucocorticoid excess in the development of abnormal AT distribution and obesity. Design Cross-sectional and case-control study. Patients Fifteen women with CD and 12 healthy controls. Measurements Mass of skeletal muscle (SM) and AT in the visceral (VAT), subcutaneous (SAT), and intermuscular (IMAT) compartments from whole-body MRI and serum levels of insulin, glucose, and leptin were measured. Results CD patients had leptin values that correlated to total AT (TAT) and SAT (P < 0·05) but not to VAT. CD patients had higher VAT/TAT ratios (P < 0·01) and lower SAT/TAT ratios (P < 0·05) compared to controls. TAT, VAT, and trunk SAT (TrSAT) were greater in CD patients (P < 0·01). SM was less in CD (P < 0·001) but IMAT was not different. Conclusions TAT, VAT, trSAT, and the proportion of AT in the visceral depot were greater in CD although the proportion in the subcutaneous depot was less. SM was less but IMAT was not different. These findings have implications for understanding the role of cortisol in the abnormal AT distribution and metabolic risk seen in patients exposed to chronic excess glucocorticoids.
AB - Objective Chronic hypercortisolemia due to Cushing's disease (CD) results in abnormal adipose tissue (AT) distribution. Whole-body magnetic resonance imaging (MRI) was used to examine lean and AT distribution in female patients with CD to further understand the role of glucocorticoid excess in the development of abnormal AT distribution and obesity. Design Cross-sectional and case-control study. Patients Fifteen women with CD and 12 healthy controls. Measurements Mass of skeletal muscle (SM) and AT in the visceral (VAT), subcutaneous (SAT), and intermuscular (IMAT) compartments from whole-body MRI and serum levels of insulin, glucose, and leptin were measured. Results CD patients had leptin values that correlated to total AT (TAT) and SAT (P < 0·05) but not to VAT. CD patients had higher VAT/TAT ratios (P < 0·01) and lower SAT/TAT ratios (P < 0·05) compared to controls. TAT, VAT, and trunk SAT (TrSAT) were greater in CD patients (P < 0·01). SM was less in CD (P < 0·001) but IMAT was not different. Conclusions TAT, VAT, trSAT, and the proportion of AT in the visceral depot were greater in CD although the proportion in the subcutaneous depot was less. SM was less but IMAT was not different. These findings have implications for understanding the role of cortisol in the abnormal AT distribution and metabolic risk seen in patients exposed to chronic excess glucocorticoids.
UR - http://www.scopus.com/inward/record.url?scp=77957026223&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2265.2010.03829.x
DO - 10.1111/j.1365-2265.2010.03829.x
M3 - Article
C2 - 20550536
AN - SCOPUS:77957026223
SN - 0300-0664
VL - 73
SP - 469
EP - 475
JO - Clinical Endocrinology
JF - Clinical Endocrinology
IS - 4
ER -