MRI and neuropathologic study of eae in the non human primate callithr1x jacchus

G. L. Mancardi, E. Capello, L. Massacesi, M. Inglese, D. Giunti, K. Nicolay, B. A. 'T Hart, A. Uccelli

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Aim of the present research is to study and analyze the evolution of demyelinating plaques in experimental allergic encephalomyelitis (EAE) produced in non human primate Callithrix jacchus by means of a correlative MRI-neuropathological study. EAE was induced with whole human myelin and T2 and Tl MRI images were carried out in vivo and right after the sacrifice of the animal. Serial sections were cut and stained with conventional stainings and immunohistochemistry; semithin sections were stained with toluidine blue and thin section were examined at EM. At MRI T2 positive areas were observed in the white matter of cerebral hemispheres, mainly around the ventricles. The neuropathologic study showed that the T2 areas were plaques of demyelination with perivascular infiltrates composed of lymphocytes and mononuclear cells. On epoxy embedded sections it was possible to confirm that the demyelination was mediated by macrophages with sparing of axons.The present MRIneuropathologic study show that the lesions observed in the EAE of marmoset have the same topographical distribution and the same pathological features of those observed in the human disorder MS.

Original languageEnglish
Pages (from-to)33
Number of pages1
JournalItalian Journal of Neurological Sciences
Issue number4
StatePublished - 1997
Externally publishedYes


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