Movement disorders and alcohol misuse

Christopher W. Hess, Rachel Saunders-Pullman

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

Many movement disorders, including tics, chorea, tremor, myoclonus and parkinsonism, may result from substance abuse. However, alcohol in particular is associated in a more complex manner with two specific movement disorders, essential tremor (ET) and myoclonus-dystonia (M-D). In this review we discuss the comorbidity of alcohol abuse in both ET and M-D, the ameliorative effects of alcohol in both diseases, and review the data evaluating alcohol abuse secondary to self-medication. We also discuss shared pathophysiologic mechanisms in the understanding of both of these disorders, as the elucidation of the mechanisms by which alcohol exerts its effects may lead to novel therapeutic approaches.

Original languageEnglish
Pages (from-to)117-125
Number of pages9
JournalAddiction Biology
Volume11
Issue number2
DOIs
StatePublished - Jun 2006
Externally publishedYes

Keywords

  • Abuse
  • Alcohol
  • Epsilon sarcoglycan
  • Essential tremor
  • Movement disorders
  • Myoclonus-dystonia

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