Mouse phenogenomics: The fast track to "systems metabolism"

Carmen A. Argmann, Pierre Chambon, Johan Auwerx

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

With the completion of the many genomes, genetics is positioned to meet physiology. In this review, we summarize the coming of "systems metabolism" in mammals through the use of the mouse, as a model system to study metabolism. Building on mouse genetics with increasingly sophisticated clinical and molecular phenotyping strategies has enabled scientists to now tackle complex biomedical questions, such as those related to the pathogenesis of the common metabolic disorders. The ultimate goal of such strategies will be to mimic human metabolism with the click of a mouse.

Original languageEnglish
Pages (from-to)349-360
Number of pages12
JournalCell Metabolism
Volume2
Issue number6
DOIs
StatePublished - Dec 2005
Externally publishedYes

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