TY - JOUR
T1 - Mouse monoclonal IgG3 antibody detecting G(D3) ganglioside
T2 - A phase I trial in patients with malignant melanoma
AU - Houghton, A. N.
AU - Mintzer, D.
AU - Cordon-Cardo, C.
AU - Welt, S.
AU - Fliegel, B.
AU - Vadhan, S.
AU - Carswell, E.
AU - Melamed, M. R.
AU - Oettgen, H. F.
AU - Old, L. J.
PY - 1985
Y1 - 1985
N2 - R24 is an IgG3 mouse monoclonal antibody that identifies G(D3), a prominent ganglioside on the surface of melanoma cells and other cells of neuroectodermal origin. Twelve patients with metastatic melanoma were treated with R24 at three dose levels, 8, 80 or 240 mg/m2, over a period of 2 weeks. Peak antibody levels in the serum were dose related and ranged from <0.1 to 62 μg/ml. Inflammatory reactions (urticaria, pruritus, erythema, subcutaneous ecchymoses) were observed around tumor sites in patients treated at doses ≥ 80 mg/m2. Tumor biopsies during and after treatment showed lymphocyte and mast cell infiltration, mast cell degranulation, and complement deposition. Side effects were mild and were readily controlled by antihistamines. Major tumor regression has been observed in three patients.
AB - R24 is an IgG3 mouse monoclonal antibody that identifies G(D3), a prominent ganglioside on the surface of melanoma cells and other cells of neuroectodermal origin. Twelve patients with metastatic melanoma were treated with R24 at three dose levels, 8, 80 or 240 mg/m2, over a period of 2 weeks. Peak antibody levels in the serum were dose related and ranged from <0.1 to 62 μg/ml. Inflammatory reactions (urticaria, pruritus, erythema, subcutaneous ecchymoses) were observed around tumor sites in patients treated at doses ≥ 80 mg/m2. Tumor biopsies during and after treatment showed lymphocyte and mast cell infiltration, mast cell degranulation, and complement deposition. Side effects were mild and were readily controlled by antihistamines. Major tumor regression has been observed in three patients.
UR - http://www.scopus.com/inward/record.url?scp=0343670252&partnerID=8YFLogxK
U2 - 10.1073/pnas.82.4.1242
DO - 10.1073/pnas.82.4.1242
M3 - Article
C2 - 3883355
AN - SCOPUS:0343670252
SN - 0027-8424
VL - 82
SP - 1242
EP - 1246
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 4
ER -