Mouse mammary tumor virus dna methylation: Tissue-specific variation

Trudy Breznik, Vicki Traina-Dorge, Miguel Gama-Sosa, Charles W. Gehrke, Melanie Ehrlich, Dan Medina, Janet S. Butel, J. Craig Cohen

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Mouse mammary tumor virus-specific DNA sequences endogenous to the BALB/c mouse are shown to exhibit variable levels of methylation in a tissue-specific manner. In DNA from both lactating mammary gland and spleen, MMTV-specific sequences were hypomethylated at specific HpaII and HhaI sites. These variably methylated sites were found in the terminal repetitive sequences of the endogenous viral genomes. The specific hypomethylation of a HpaII site in Mtv-9 is associated with expression of a 1.6 kb transcript in the lactating mammary gland.

Original languageEnglish
Pages (from-to)69-77
Number of pages9
JournalVirology
Volume136
Issue number1
DOIs
StatePublished - 15 Jul 1984
Externally publishedYes

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