Mouse dendritic cell (DC) influenza virus infectivity is much lower than that for human DCs and is hemagglutinin subtype dependent

Boris M. Hartmann, Wenjing Li, Jingjing Jia, Sonali Patil, Nada Marjanovic, Carles Martínez-Romero, Randy A. Albrecht, Hayot Fernand Hayot, García-Sastre Adolfo García-Sastre, James G. Wetmur, Thomas M. Moran, Stuart C. Sealfon

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

We show that influenza A H1N1 virus infection leads to very low infectivity in mouse dendritic cells (DCs) in vitro compared with that in human DCs. This holds when H3 or H5 replaces H1 in recombinant viruses. Viruslike particles confirm the difference between mouse and human, suggesting that reduced virus entry contributes to lower mouse DC infectivity. Low infectivity of mouse DCs should be considered when they are used to study responses of DCs that are actually infected.

Original languageEnglish
Pages (from-to)1916-1918
Number of pages3
JournalJournal of Virology
Volume87
Issue number3
DOIs
StatePublished - Feb 2013

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