Motor neuron diseases and amyotrophic lateral sclerosis: GM1 antibodies and paraproteinemia

K. A. Sanders, L. P. Rowland, P. L. Murphy, D. S. Younger, N. Latov, W. H. Sherman, M. Pesce, D. J. Lange

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Six of 110 patients (5.5%) with forms of motor neuron disease had abnormal titers of GM1 antibodies of 1:1,600 or higher. Four others came with previously known high titers. Three patients with upper motor neuron (UMN) signs had titers of 1,600; those with probable or no UMN signs had higher titers. Nine patients had conduction block; six of them had abnormal antibody titers, four with 6,400 or higher. Therefore, patients with motor neuron disease and abnormal anti-GM1 titers may have UMN signs or conduction block.

Original languageEnglish
Pages (from-to)418-420
Number of pages3
JournalNeurology
Volume43
Issue number2
StatePublished - Feb 1993
Externally publishedYes

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