Motor nerve ending disorder in myasthenia gravis

Robert D. Roe, Walter F. Riker, Frank G. Standaert

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Mild myasthenia gravis patients were compared with normals with respect to the capacity of their motor nerve endings (MNEs) to generate a neostigmine-induced postactivation repetition (PAR). Dose-response analyses of PAR recorded from muscle electrically and by contractile measurement disclose a loss of this pharmacologic responsiveness in myasthenia. Since mild myasthenics transmitted nerve impulse trains of 20 to 200 Hz, as did normals, it was evident that PAR is transmitted insofar as it can be generated by MNEs. The dose-response analyses support this. These data indicate an MNE disorder in the disease.

Original languageEnglish
Pages (from-to)293-297
Number of pages5
Issue number2
StatePublished - Feb 1988


Dive into the research topics of 'Motor nerve ending disorder in myasthenia gravis'. Together they form a unique fingerprint.

Cite this