Motif-based construction of a functional map for mammalian olfactory receptors

Agatha H. Liu, Xinmin Zhang, Gustavo A. Stolovitzky, Andrea Califano, Stuart J. Firestein

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

We applied an automatic and unsupervised system to a nearly complete database of mammalian odor receptor genes. The generated motifs and gene classification were subjected to extensive and systematic downstream analysis to obtain biological insights. Two major results from this analysis were: (1) a map of sequence motifs that may correlate with function and (2) the corresponding receptor classes in which members of each class are likely to share specific functions. We have discovered motifs that have been implicated in structural integrity and posttranslational modification, as well as motifs very likely to be directly involved in ligand binding. We further propose a combinatorial molecular hypothesis, based on unique combinations of the observed motifs, that provides a foundation for understanding the generation of a large number of ligand binding sites.

Original languageEnglish
Pages (from-to)443-456
Number of pages14
JournalGenomics
Volume81
Issue number5
DOIs
StatePublished - 1 May 2003
Externally publishedYes

Keywords

  • Bioinformatics
  • Genome
  • Motif
  • Olfactory receptor

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