TY - JOUR
T1 - Mosaic Hemagglutinin-Based Whole Inactivated Virus Vaccines Induce Broad Protection Against Influenza B Virus Challenge in Mice
AU - Liu, Yonghong
AU - Strohmeier, Shirin
AU - González-Domínguez, Irene
AU - Tan, Jessica
AU - Simon, Viviana
AU - Krammer, Florian
AU - García-Sastre, Adolfo
AU - Palese, Peter
AU - Sun, Weina
N1 - Publisher Copyright:
© Copyright © 2021 Liu, Strohmeier, González-Domínguez, Tan, Simon, Krammer, García-Sastre, Palese and Sun.
PY - 2021/9/16
Y1 - 2021/9/16
N2 - Influenza viruses undergo antigenic changes in the immuno-dominant hemagglutinin (HA) head domain, necessitating annual re-formulation of and re-vaccination with seasonal influenza virus vaccines for continuing protection. We previously synthesized mosaic HA (mHA) proteins of influenza B viruses which redirect the immune response towards the immuno-subdominant conserved epitopes of the HA via sequential immunization. As ~90% of current influenza virus vaccines are manufactured using the inactivated virus platform, we generated and sequentially vaccinated mice with inactivated influenza B viruses displaying either the homologous (same B HA backbones) or the heterologous (different B HA backbones) mosaic HAs. Both approaches induced long-lasting and cross-protective antibody responses showing strong antibody-dependent cellular cytotoxicity (ADCC) activity. We believe the B virus mHA vaccine candidates represent a major step towards a universal influenza B virus vaccine.
AB - Influenza viruses undergo antigenic changes in the immuno-dominant hemagglutinin (HA) head domain, necessitating annual re-formulation of and re-vaccination with seasonal influenza virus vaccines for continuing protection. We previously synthesized mosaic HA (mHA) proteins of influenza B viruses which redirect the immune response towards the immuno-subdominant conserved epitopes of the HA via sequential immunization. As ~90% of current influenza virus vaccines are manufactured using the inactivated virus platform, we generated and sequentially vaccinated mice with inactivated influenza B viruses displaying either the homologous (same B HA backbones) or the heterologous (different B HA backbones) mosaic HAs. Both approaches induced long-lasting and cross-protective antibody responses showing strong antibody-dependent cellular cytotoxicity (ADCC) activity. We believe the B virus mHA vaccine candidates represent a major step towards a universal influenza B virus vaccine.
KW - broad protection
KW - immuno-subdominant epitopes
KW - influenza B virus
KW - universal influenza B vaccine
KW - whole inactivated virus vaccine
UR - http://www.scopus.com/inward/record.url?scp=85116225722&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2021.746447
DO - 10.3389/fimmu.2021.746447
M3 - Article
C2 - 34603333
AN - SCOPUS:85116225722
SN - 1664-3224
VL - 12
JO - Frontiers in Immunology
JF - Frontiers in Immunology
M1 - 746447
ER -